EFFECTS OF L-STEPHOLIDINE ON SYNAPTOSOMAL CA2+-ATPASE AND SUBCELLULAR CALMODULIN IN RAT STRIATUM
文献类型：期刊论文
| 作者 | HU, G; HU, Y; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-07 |
| 卷号 | 13期号:4页码:307-311 |
| 关键词 | BERBINES L-STEPHOLIDINE CORPUS STRIATUM SYNAPTOSOMES CALCIUM ADENOSINE TRIPHOSPHATASE CALMODULIN |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Our results showed that l-stepholidine (l-SPD) inhibited basal Ca2+ -ATPase activity in rat striatal synaptosomes with an IC50 of 31.5 mu-mol . L-1, suggesting its interaction with Ca2+ transport. l-SPD inhibited also calmodulin (CaM)-activated basal Ca2+ -ATPase in a concentration-dependent manner. A complete reversal of CaM activation of Ca2+ -ATPase was observed with l-SPD 10-mu-mol . L-1. The activity of synaptosomal Ca2+ -ATPase and membrane-bound CaM level were decreased in haloperidol (1 mg . kg-1 . d-1, ip) and l-SPD (5, 10, and 30 mg . kg-1 . d-1, ip) and for 7 and 14 d, respectively. But the activity of Ca2+ -ATPase and membrane CaM level were increased after treatment with the same of doses haloperidol and l-SPD for 21 d. During the treatments with haloperidol and l-SPD cytosolic and nuclear CaM levels were not altered. These results suggest that l-SPD may modulate the release and synthesis of dopamine (DA) and the negative feedback regulation of presynaptic DA receptors by altering Ca2+ and CaM regulating processes in the central dopaminergic nervous system. |
| WOS关键词 | BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:937318 |
| WOS记录号 | WOS:A1992JD14000005 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275160]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | HU, G |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | HU, G,HU, Y,JIN, GZ. EFFECTS OF L-STEPHOLIDINE ON SYNAPTOSOMAL CA2+-ATPASE AND SUBCELLULAR CALMODULIN IN RAT STRIATUM[J]. ACTA PHARMACOLOGICA SINICA,1992,13(4):307-311. |
| APA | HU, G,HU, Y,&JIN, GZ.(1992).EFFECTS OF L-STEPHOLIDINE ON SYNAPTOSOMAL CA2+-ATPASE AND SUBCELLULAR CALMODULIN IN RAT STRIATUM.ACTA PHARMACOLOGICA SINICA,13(4),307-311. |
| MLA | HU, G,et al."EFFECTS OF L-STEPHOLIDINE ON SYNAPTOSOMAL CA2+-ATPASE AND SUBCELLULAR CALMODULIN IN RAT STRIATUM".ACTA PHARMACOLOGICA SINICA 13.4(1992):307-311. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。