HEMODYNAMIC ACTIONS OF GUAN-FU BASE A IN ANESTHETIZED RATS
文献类型：期刊论文
| 作者 | WANG, YP ; CHEN, WZ; SUN, WK; WU, JX
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-05 |
| 卷号 | 13期号:3页码:231-234 |
| 关键词 | GUAN-FU BASE A PROPRANOLOL HEMODYNAMICS BRADYCARDIA ACONITE |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Guan-fu base A (GFA) is a terpenoid alkaloid isolated from the tuber of Aconitum coreanum in this institute. GFA exhibited anti-arrhythmic effects in various experimental arrhythmia animal models, and bradycardic actions. In this paper, the hemodynamic action of GFA was investigated. GFA 20 mg . kg-1 iv decreased in heart rate from 420 +/- 51 to 305 +/- 60 bpm (P < 0.05). The changes of SBP, DBP, LVSP, +/- dP/dt(max), and LVEDP were much smaller or insignificant. GFA(1, 3, 10, 30, 60 mg . kg-1 cumulative iv) increased the heart periods (HP) and QT-intervals in a dose-dependent manner, accompanied by a small increase in PQ-interval, but did not affect QRS complex. The increase in HP from 138 +/- 11 to 321 +/- 48 ms (P < 0.01) was mainly due to a prolongation of the diastolic period from 22 +/- 12 ms to 156 +/- 46 ms (P < 0.01). The triple product of HR x LVET x SBP was also decreased with every dose of GFA. This hemodynamic profile suggests that the bradycardic action of GFA can reduce myocardial oxygen consumption and improve myocardial blood supply, which may be of use in certain cardiac patients. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:191974 |
| WOS记录号 | WOS:A1992HT97500010 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275164]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | WANG, YP |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | WANG, YP,CHEN, WZ,SUN, WK,et al. HEMODYNAMIC ACTIONS OF GUAN-FU BASE A IN ANESTHETIZED RATS[J]. ACTA PHARMACOLOGICA SINICA,1992,13(3):231-234. |
| APA | WANG, YP,CHEN, WZ,SUN, WK,&WU, JX.(1992).HEMODYNAMIC ACTIONS OF GUAN-FU BASE A IN ANESTHETIZED RATS.ACTA PHARMACOLOGICA SINICA,13(3),231-234. |
| MLA | WANG, YP,et al."HEMODYNAMIC ACTIONS OF GUAN-FU BASE A IN ANESTHETIZED RATS".ACTA PHARMACOLOGICA SINICA 13.3(1992):231-234. |
入库方式： OAI收割
来源：上海药物研究所
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