LACK OF MUTAGENICITY AND TERATOGENICITY OF 16-METHYLENE-17-ALPHA-ACETOXY-19-NORPROGESTERONE
文献类型：期刊论文
| 作者 | TU, ZH; WANG, MY; QI, XD; XU, WB; XU, DH |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1992-03 |
| 卷号 | 13期号:2页码:183-186 |
| 关键词 | NORPROGESTERONES CHROMOSOME ABERRATIONS MICRONUCLEUS TESTS MUTAGENICITY TESTS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | 16-Methylene-17-alpha-acetoxy-19-norprogesterone (ST-1435) is a new antifertility agent. ST-1435 silastic capsule was implanted sc in the nuchal region of rats on d 6 of gestation at 75, 300, and 600 mg . kg-1. The rats were killed on d 20. In comparison with the control, the treated groups showed no significant differences in maternal body weights, number of corpora lutea, and the development of embryos and fetuses. The number of dead fetuses decreased and live fetuses increased slightly. ST-1435 did not affect the frequency of micronucleated polychromatic erythrocytes, nor induce chromosomal aberrations in cultured CHL cells, or increase the revertants of Salmonella typhimurium TA97, TA98, TA100, and TA102 in Ames test. The results suggested that ST-1435 had neither teratogenicity nor mutagenicity. |
| WOS关键词 | CELLS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:191985 |
| WOS记录号 | WOS:A1992HH11200024 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275171]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | TU, ZH |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | TU, ZH,WANG, MY,QI, XD,et al. LACK OF MUTAGENICITY AND TERATOGENICITY OF 16-METHYLENE-17-ALPHA-ACETOXY-19-NORPROGESTERONE[J]. ACTA PHARMACOLOGICA SINICA,1992,13(2):183-186. |
| APA | TU, ZH,WANG, MY,QI, XD,XU, WB,&XU, DH.(1992).LACK OF MUTAGENICITY AND TERATOGENICITY OF 16-METHYLENE-17-ALPHA-ACETOXY-19-NORPROGESTERONE.ACTA PHARMACOLOGICA SINICA,13(2),183-186. |
| MLA | TU, ZH,et al."LACK OF MUTAGENICITY AND TERATOGENICITY OF 16-METHYLENE-17-ALPHA-ACETOXY-19-NORPROGESTERONE".ACTA PHARMACOLOGICA SINICA 13.2(1992):183-186. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。