EFFECT OF (-)-STEPHOLIDINE ON BLOOD-PRESSURE AND ALPHA-ADRENOCEPTOR AGONISTS-EVOKED, KCL-EVOKED AND CACL2-EVOKED CONTRACTIONS OF AORTIC STRIPS
文献类型：期刊论文
| 作者 | SHEN, DL; JIN, GZ ; HE, YF; ZHANG, ZD; SUN, Z; YANG, ZC
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-11 |
| 卷号 | 12期号:6页码:514-518 |
| 关键词 | STEPHOLIDINE ANTIHYPERTENSIVE AGENTS THORACIC AORTA RENAL ARTERY RESERPINE |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | Iv (-)-SPD lowered the blood pressure in anesthetized rat, the ED50 value was 5.1 +/- 2.5 mg . kg-1. In the experiments of rat and rabbit aortic strips, (-)-SPD 0.3-100.0-mu-mol . L-1 inhibited the contraction initiated by clonidine (alpha-2) and phenylephrine (alpha-1) and shifted the dose-response curve to the right parallely without change in maxium response. The inhibitory ratio of (-)-SPD acting on alpha-2/alpha-1 adrenergic receptors was about 7.2, and (-)-SPD thus was predominant inhibition on alpha-2 adrenergic receptors. In the experiment of aortic strips from reserpinized rabbits, the inhibition of (-)-SPD on contraction evoked by clonidine was diminished markedly. The results suggest that (-)-SPD stimulated mainly the alpha-2-adrenergic receptors of presynaptic nerve endings. Morever (-)-SPD 1-mu-mol . L-1 inhibited the release of intracellular Ca2+ initiated by NE. (-)-SPD 3-30-mu-mol . L-1 blocked the voltage-dependent Ca2+ channel. |
| WOS关键词 | L-STEPHOLIDINE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1991GP71000009 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275188]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.CHINESE ACAD SCI, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA 2.SHANGHAI MED UNIV, DEPT PHARMACOL, SHANGHAI 200032, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | SHEN, DL,JIN, GZ,HE, YF,et al. EFFECT OF (-)-STEPHOLIDINE ON BLOOD-PRESSURE AND ALPHA-ADRENOCEPTOR AGONISTS-EVOKED, KCL-EVOKED AND CACL2-EVOKED CONTRACTIONS OF AORTIC STRIPS[J]. ACTA PHARMACOLOGICA SINICA,1991,12(6):514-518. |
| APA | SHEN, DL,JIN, GZ,HE, YF,ZHANG, ZD,SUN, Z,&YANG, ZC.(1991).EFFECT OF (-)-STEPHOLIDINE ON BLOOD-PRESSURE AND ALPHA-ADRENOCEPTOR AGONISTS-EVOKED, KCL-EVOKED AND CACL2-EVOKED CONTRACTIONS OF AORTIC STRIPS.ACTA PHARMACOLOGICA SINICA,12(6),514-518. |
| MLA | SHEN, DL,et al."EFFECT OF (-)-STEPHOLIDINE ON BLOOD-PRESSURE AND ALPHA-ADRENOCEPTOR AGONISTS-EVOKED, KCL-EVOKED AND CACL2-EVOKED CONTRACTIONS OF AORTIC STRIPS".ACTA PHARMACOLOGICA SINICA 12.6(1991):514-518. |
入库方式： OAI收割
来源：上海药物研究所
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