NO PROMOTING EFFECTS OF SODIUM TANSHINONE-II-A SULFONATE ON GROWTH AND METASTASIS OF LEWIS CARCINOMA
文献类型：期刊论文
| 作者 | LIU, MZ; HUANG, YS; XIAO, WQ |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-11 |
| 卷号 | 12期号:6页码:534-537 |
| 关键词 | SALVIA-MILTIORRHIZA TANSHINONE-II-A SULFONATE LUNG NEOPLASMS NEOPLASM METASTASIS INBRED C57BL MICE |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | From d 3 after transplantation of Lewis pulmonary carcinoma in C57BL mouse leg muscles, the mice were injected ip sodium tanshinone II-A sulfonate (DS-201) 0.2, 0.4, 6.3, 12.5, 25.0, and 50.0 mg . kg-1 qd x 12 d. At the dose of 12.5 mg . kg-1 or below, the mice appeared to be as vivid as those of the control. In the group of 25 mg . kg-1, declining brisk and unkempt appearances were seen. At 50 mg . kg-1, the mice were more emaciated and half of them died. On d 2 of cessation of the medication, all remaining mice were dissected. The weights of muscle tumors and the metastatic foci on lungs in the medicated mice showed no significant differences from their controls. These results demonstrate that DS-201 has no promoting effect both on growth of Lewis carcinoma transplanted in C57BL mouse leg muscles and on lung metastasis of the neoplasm. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:162116 |
| WOS记录号 | WOS:A1991GP71000015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275189]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | LIU, MZ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | LIU, MZ,HUANG, YS,XIAO, WQ. NO PROMOTING EFFECTS OF SODIUM TANSHINONE-II-A SULFONATE ON GROWTH AND METASTASIS OF LEWIS CARCINOMA[J]. ACTA PHARMACOLOGICA SINICA,1991,12(6):534-537. |
| APA | LIU, MZ,HUANG, YS,&XIAO, WQ.(1991).NO PROMOTING EFFECTS OF SODIUM TANSHINONE-II-A SULFONATE ON GROWTH AND METASTASIS OF LEWIS CARCINOMA.ACTA PHARMACOLOGICA SINICA,12(6),534-537. |
| MLA | LIU, MZ,et al."NO PROMOTING EFFECTS OF SODIUM TANSHINONE-II-A SULFONATE ON GROWTH AND METASTASIS OF LEWIS CARCINOMA".ACTA PHARMACOLOGICA SINICA 12.6(1991):534-537. |
入库方式： OAI收割
来源：上海药物研究所
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