SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS
文献类型：期刊论文
| 作者 | XU, J; LIANG, YY; ZHANG, JS; YAN, XM |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-09 |
| 卷号 | 12期号:5页码:441-& |
| 关键词 | DIMERCAPTOSUCCINIC ACID NICKEL TISSUE DISTRIBUTION AUTORADIOGRAPHY GEL CHROMATOGRAPHY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | In mice and rats given iv or im (NiCl2)-Ni-63 148-370 kBq, radioactivity was present in highest concentrations in kidney, lung, and liver. After given ig dimercaptosuccinic acid (DMSA) 1 g.kg-1, radioactivity decreased remarkably in kidney, lung, and blood. The excretion of Ni-63 via urine and feces within 24 h, respectively 13.0 +/- 2.4% and 0.6 +/- 0.4%, was similar to that in the control group in mice. But radioactivity increased markedly in bone. The Ni content of bone decreased on d 7. In rats given im (NiCl2)-Ni-63 370 kBq, two different nickel complex peaks appeared in the gel chromatograms of serum, kidney, and lung. DMSA reduced the contents of protein-bound Ni in serum, kidney, and lung. The results showed that DMSA detoxified the Ni by forming a low toxicity Ni-DMSA complex to redistribute in the body. |
| WOS关键词 | PULMONARY TUMOR RESPONSE ; STRAIN-A MICE ; METALLIC COMPOUNDS ; CARCINOGENICITY |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:162153 |
| WOS记录号 | WOS:A1991GE60900015 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275192]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | XU, J |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | XU, J,LIANG, YY,ZHANG, JS,et al. SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS[J]. ACTA PHARMACOLOGICA SINICA,1991,12(5):441-&. |
| APA | XU, J,LIANG, YY,ZHANG, JS,&YAN, XM.(1991).SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS.ACTA PHARMACOLOGICA SINICA,12(5),441-&. |
| MLA | XU, J,et al."SCAVENGING EFFECTS OF DIMERCAPTOSUCCINIC ACID PER OS ON NICKEL IN MICE AND RATS".ACTA PHARMACOLOGICA SINICA 12.5(1991):441-&. |
入库方式： OAI收割
来源：上海药物研究所
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