SULPIRIDE ATTENUATES RANATENSIN-M-INDUCED ANTINOCICEPTION
文献类型：期刊论文
| 作者 | ZHU, XZ; JI, XQ; WU, SX; ZOU, G |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-07 |
| 卷号 | 12期号:4页码:291-293 |
| 关键词 | RANATENSIN-M BOMBESIN SCH-23390 SULPIRIDE DOPAMINE RECEPTOR BLOCKERS ANALGESIA |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | Intracerebroventricular (icv) administration of ranatensin-M (RM), a bombesin-like peptide isolated from the skin of Chinese frog Rana margaratae, produced a dose-dependent prolongation in the hot-plate latency in mice. Naloxone 1, 2, or 10 mg.kg-1 ip failed to antagonize the effects of RM. However, RM-induced antinociception was attenuated by pretreatment with sulpiride (Sul, 100 mg.kg-1, ip), a selective DA2 receptor blocker. Sul (100 mg.kg-1, ip) did not affect hot-plate latencies when administered alone. Sch 23390 (0.2 mg.kg-1, ip), a selective DA1 receptor blocker, did not significantly affect RM-induced antinociception. The results suggest that RM-induced antinociception may be mediated by dopamine neurotransmission within the CNS and that it is mainly the D2 receptor which was involved in this effects. |
| WOS关键词 | BOMBESIN-LIKE PEPTIDES ; RAT ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1991FW03500001 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275195]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | ZHU, XZ |
| 作者单位 | CHINESE ACAD SCI, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | ZHU, XZ,JI, XQ,WU, SX,et al. SULPIRIDE ATTENUATES RANATENSIN-M-INDUCED ANTINOCICEPTION[J]. ACTA PHARMACOLOGICA SINICA,1991,12(4):291-293. |
| APA | ZHU, XZ,JI, XQ,WU, SX,&ZOU, G.(1991).SULPIRIDE ATTENUATES RANATENSIN-M-INDUCED ANTINOCICEPTION.ACTA PHARMACOLOGICA SINICA,12(4),291-293. |
| MLA | ZHU, XZ,et al."SULPIRIDE ATTENUATES RANATENSIN-M-INDUCED ANTINOCICEPTION".ACTA PHARMACOLOGICA SINICA 12.4(1991):291-293. |
入库方式： OAI收割
来源：上海药物研究所
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