EFFECT OF L-4-OXALYSINE ON ULTRASTRUCTURES OF LIVER-CELLS IN MICE
文献类型：期刊论文
| 作者 | DAI, ZQ; YU, YG; ZHU, PP; YUAN, XJ; XU, JY; LI, XY |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-07 |
| 卷号 | 12期号:4页码:336-& |
| 关键词 | LYSINE LIVER LIPIDS STEATOSIS ELECTRON MICROSCOPY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Mice were given ig L-4-oxalysine (I-677) 10, 50, and 100 mg . kg-1 . d-1 for 7 d. On d 8 the hepatocytes showed accumulation of lipid droplets followed by loss of matrices in cytoplasm. The total area of lipid droplets was far less than 25% of mean section of hepatocytes. The injury of mitochondria and RER was only found in the groups of medium and high dose. The lipidoses and regional topolysis of cytoplasm graduated away at same pace. After 4 wk the hepatocytes were restored to normal. Such finding suggests that the site of action of I-677 be at the cytoplasmic ground substance. The inhibition of protein synthesis causes a decrease in albumin carrier, that may be the main mechanism of steatosis of liver cells induced by I-677. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:162174 |
| WOS记录号 | WOS:A1991FW03500013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275196]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | DAI, ZQ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | DAI, ZQ,YU, YG,ZHU, PP,et al. EFFECT OF L-4-OXALYSINE ON ULTRASTRUCTURES OF LIVER-CELLS IN MICE[J]. ACTA PHARMACOLOGICA SINICA,1991,12(4):336-&. |
| APA | DAI, ZQ,YU, YG,ZHU, PP,YUAN, XJ,XU, JY,&LI, XY.(1991).EFFECT OF L-4-OXALYSINE ON ULTRASTRUCTURES OF LIVER-CELLS IN MICE.ACTA PHARMACOLOGICA SINICA,12(4),336-&. |
| MLA | DAI, ZQ,et al."EFFECT OF L-4-OXALYSINE ON ULTRASTRUCTURES OF LIVER-CELLS IN MICE".ACTA PHARMACOLOGICA SINICA 12.4(1991):336-&. |
入库方式： OAI收割
来源：上海药物研究所
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