DRUG-EVALUATION OF HUPERZINE-A IN THE TREATMENT OF SENILE MEMORY DISORDERS
文献类型：期刊论文
| 作者 | ZHANG, RW; TANG, XC ; HAN, YY; SANG, GW; ZHANG, YD; MA, YX; ZHANG, CL; YANG, RM
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-05 |
| 卷号 | 12期号:3页码:250-252 |
| 关键词 | HUPERZINE-A MEMORY DISORDERS SENILE DEMENTIA MULTIINFARCT DEMENTIA DRUG EVALUATION |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Huperzine A is an alkoloid which was first isolated from Huperzia serrata (Thumb) Trev by Zhejiang Academy of Medical Sciences and Shanghai Institute of Materia Medica, Chinese Academy of Sciences. It exhibits a significant anticholinesterase activity and has been used on myasthenia gravis patients. The therapeutic effects were studied by random, match and double-blind method on 56 patients of multi-infarct dementia or senile dementia and 104 patients of senile and presenile simple memory disorders. The curative effects were evaluated by Wechsler memory scale. The im dose for multi-infarct dementia was 0.05 mg bid for 4 wk, whereas that for senile and presenile simple memory disorders was 0.03 mg bid for 2 wk. Saline was used on control group. The result showed that the curative effect of huperzine A was significant. Only a few patients felt slight dizziness and this did not affect the therapeutic effects. |
| WOS关键词 | DISCRIMINATION PERFORMANCE ; RATS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1991FL66500016 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275199]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.SHANGHAI HUADONG HOSP,SHANGHAI 200040,PEOPLES R CHINA 2.ANHUEI CHINESE TRADIT MED COLL,AFFILIATED HOSP,HEFEI 230000,PEOPLES R CHINA 3.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA 4.JIAOJIANG PEOPLES HOSP,JIAOJIANG 317700,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | ZHANG, RW,TANG, XC,HAN, YY,et al. DRUG-EVALUATION OF HUPERZINE-A IN THE TREATMENT OF SENILE MEMORY DISORDERS[J]. ACTA PHARMACOLOGICA SINICA,1991,12(3):250-252. |
| APA | ZHANG, RW.,TANG, XC.,HAN, YY.,SANG, GW.,ZHANG, YD.,...&YANG, RM.(1991).DRUG-EVALUATION OF HUPERZINE-A IN THE TREATMENT OF SENILE MEMORY DISORDERS.ACTA PHARMACOLOGICA SINICA,12(3),250-252. |
| MLA | ZHANG, RW,et al."DRUG-EVALUATION OF HUPERZINE-A IN THE TREATMENT OF SENILE MEMORY DISORDERS".ACTA PHARMACOLOGICA SINICA 12.3(1991):250-252. |
入库方式： OAI收割
来源：上海药物研究所
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