EFFECTS OF L-STEPHOLIDINE ON ISOLATED RABBIT BASILAR ARTERY, MESENTERIC-ARTERY, AND THORACIC AORTA
文献类型：期刊论文
| 作者 | MIAO, YS; ZHANG, AZ; LIN, C; JIANG, MH; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-05 |
| 卷号 | 12期号:3页码:260-262 |
| 关键词 | STEPHOLIDINE BASILAR ARTERY MESENTERIC ARTERIES THORACIC AORTA DRUG DOSE-RESPONSE RELATIONSHIP KETANSERIN |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | l-Stepholidine (SPD) has been shown to be effective in treating migraine, but its mechanism is not clear. So the effects of SPD on isolated rabbit basilar artery (BA), mesenteric artery (MA) and thoracic aorta (TA) were studied. The contractions of BA and MA were induced by KCl (10-160 mmol . L-1) and the contraction of TA was caused by 5-HT (0.1-100-mu-mol . L-1). Ketanserin was used as reference. SPD (0.1-0.2 mmol . L-1) relaxed the contractions of BA and MA induced by KCl in a noncompetitive manner with pD2' 3.4 +/- 0.3 and 4.0 +/- 0.3, respectively. SPD had no selectivity in BA and MA. SPD also inhibited the contraction of TA induced by 5-HT with pA2 9.7 +/- 2.0 and pD2' 5.4 +/- 0.6, which showed a dual of both competetive and noncompetetive antagonisms. These results suggested that SPD had a blockade effect on the calcium channel and 5-HT2 receptors. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1991FL66500019 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275200]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | MIAO, YS |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | MIAO, YS,ZHANG, AZ,LIN, C,et al. EFFECTS OF L-STEPHOLIDINE ON ISOLATED RABBIT BASILAR ARTERY, MESENTERIC-ARTERY, AND THORACIC AORTA[J]. ACTA PHARMACOLOGICA SINICA,1991,12(3):260-262. |
| APA | MIAO, YS,ZHANG, AZ,LIN, C,JIANG, MH,&JIN, GZ.(1991).EFFECTS OF L-STEPHOLIDINE ON ISOLATED RABBIT BASILAR ARTERY, MESENTERIC-ARTERY, AND THORACIC AORTA.ACTA PHARMACOLOGICA SINICA,12(3),260-262. |
| MLA | MIAO, YS,et al."EFFECTS OF L-STEPHOLIDINE ON ISOLATED RABBIT BASILAR ARTERY, MESENTERIC-ARTERY, AND THORACIC AORTA".ACTA PHARMACOLOGICA SINICA 12.3(1991):260-262. |
入库方式： OAI收割
来源：上海药物研究所
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