ANTIFERTILITY EFFECT OF THE IMPLANT CONTAINING 16-METHYLENE-17 ALPHA-ACETOXY-19-NORPROGESTERONE (ST-1435)
文献类型：期刊论文
| 作者 | CHU, ZW; WANG, WC; WANG, YE; YOU, GD; GU, ZP |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-05 |
| 卷号 | 12期号:3页码:285-288 |
| 关键词 | SYNTHETIC PROGESTATIONAL HORMONES FEMALE CONTRACEPTIVE AGENTS DELAYED-ACTION PREPARATIONS |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | The silastic capsules containing ST-1435 (0.5, 1, 2, 4, 6 or 8 mg) showed "burst effect" with a peak value of 4-15-mu-g . h-1 after incubation in vitro. A constant release rate was gradually approached within 1-2 wk. After the capsules were subcutaneous implanted or vaginally administrated, the rats manifested diestrus within 24-48 h. The normal estrus cycles and fertility were restored as soon as the release rate of implants decreased to 10-mu-g . d-1 in vitro. ST-1435 did not inhibit the superovulation induced by PMSG and HCG in immature female rats, but blocked the ovulation induced by LHRH in mature rats. |
| WOS关键词 | CONTROLLED DRUG RELEASE ; PROGESTIN ST-1435 ; CAPSULES ; MECHANISMS ; DEVICES |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1991FL66500026 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275201]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | CHU, ZW |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | CHU, ZW,WANG, WC,WANG, YE,et al. ANTIFERTILITY EFFECT OF THE IMPLANT CONTAINING 16-METHYLENE-17 ALPHA-ACETOXY-19-NORPROGESTERONE (ST-1435)[J]. ACTA PHARMACOLOGICA SINICA,1991,12(3):285-288. |
| APA | CHU, ZW,WANG, WC,WANG, YE,YOU, GD,&GU, ZP.(1991).ANTIFERTILITY EFFECT OF THE IMPLANT CONTAINING 16-METHYLENE-17 ALPHA-ACETOXY-19-NORPROGESTERONE (ST-1435).ACTA PHARMACOLOGICA SINICA,12(3),285-288. |
| MLA | CHU, ZW,et al."ANTIFERTILITY EFFECT OF THE IMPLANT CONTAINING 16-METHYLENE-17 ALPHA-ACETOXY-19-NORPROGESTERONE (ST-1435)".ACTA PHARMACOLOGICA SINICA 12.3(1991):285-288. |
入库方式： OAI收割
来源：上海药物研究所
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