L-TETRAHYDROPALMATINE INCREASES LEUCINE ENKEPHALIN LEVELS IN CORPUS STRIATUM OF RATS
文献类型：期刊论文
| 作者 | ZHU, XZ; ZHOU, Z; JI, XQ; GU, J; LUO, LG; WANG, FS |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-03 |
| 卷号 | 12期号:2页码:104-107 |
| 关键词 | L-TETRAHYDROPALMATINE SCH-23390 SULPIRIDE DOPAMINE RECEPTOR BLOCKADERS LEUCINE ENKEPHALIN CORPUS STRIATUM |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | The effect of chronic l-tetrahydropalmatine (l-THP) administration on the level of leucine enkephalin (Leu-Enk) in rat corpus striatum was studied. After l-THP sc injection once daily for 2 wk, the striatal Leu-Enk level was elevated dose-dependently. However, a single injection of l-THP failed to change the Leu-Enk level. When rats received sc Sch-23390, a selective D1 antagonist, 15 nmol . kg-1 tid for 2 wk, striatal content of Leu-Enk increased from 0.17 +/- SD 0.03 ng . mg-1 tissue in control group to 0.23 +/- SD 0.05 ng . mg-1 tissue in Sch-23390 group (n = 8, P < 0.05). Sulpiride (Sul), a selective D2 antagonist, 140 mu-mol . kg-1 sc given bid for 2 wk had no significant effect on the striatal Leu-Enk content. The results suggested that the blockade of D1 receptors by l-THP might be responsible for the increase of the striatal Leu-Enk content in rat. |
| WOS关键词 | MESSENGER-RNA ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:A1991FB87500002 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275204]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | ZHU, XZ |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | ZHU, XZ,ZHOU, Z,JI, XQ,et al. L-TETRAHYDROPALMATINE INCREASES LEUCINE ENKEPHALIN LEVELS IN CORPUS STRIATUM OF RATS[J]. ACTA PHARMACOLOGICA SINICA,1991,12(2):104-107. |
| APA | ZHU, XZ,ZHOU, Z,JI, XQ,GU, J,LUO, LG,&WANG, FS.(1991).L-TETRAHYDROPALMATINE INCREASES LEUCINE ENKEPHALIN LEVELS IN CORPUS STRIATUM OF RATS.ACTA PHARMACOLOGICA SINICA,12(2),104-107. |
| MLA | ZHU, XZ,et al."L-TETRAHYDROPALMATINE INCREASES LEUCINE ENKEPHALIN LEVELS IN CORPUS STRIATUM OF RATS".ACTA PHARMACOLOGICA SINICA 12.2(1991):104-107. |
入库方式： OAI收割
来源：上海药物研究所
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