ENDOCRINE ACTIVITY OF PSEUDOLARIC ACID-A AND PSEUDOLARIC ACID-B AND THEIR EFFECTS ON SEX-HORMONES, PROSTAGLANDINS, UTERI, AND FETUSES
文献类型：期刊论文
| 作者 | WANG, WC; YOU, GD; JIANG, XJ; LU, RF; GU, ZP |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-03 |
| 卷号 | 12期号:2页码:187-190 |
| 关键词 | PSEUDOLARIC ACID FEMALE CONTRACEPTIVE AGENTS PROGESTERONE ESTRADIOL PROSTAGLANDINS DECIDUA TROPHOBLAST |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Two novel diterpendoids, pseudolaric acids A and B (PA, PB) first isolated from the root of Pseudolarix kaempferi Gorden in China, have been reported to possess significant antifertile activities in rats, hamsters, rabbits, and dogs. The present study demonstrated that neither PA nor PB had estrogenic and antiestrogenic activities, they also did not inhibit deciduous formation. When an effective dose of PB 30 mg . kg-1 was given on d 6 of pregnancy and the hormonal determinations were done on d 8 and d 12 of pregnancy, the progesterone, estradiol and prostaglandins E, F levels in plasma and the uterine prostaglandine E, F levels were not significantly reduced vs those of the control rats. The human uterus was used as the experimental material in vitro. PA and PB 200-mu-g . ml-1 cultural medium (McCoy's 5a medium) damaged only a part of the decidual and trophoblast cells. In partially depolarized isolated uterine smooth muscles of early pregnant rats, PA and PB caused a decline in the contractile tension. A low dose of PB 2 mg . kg-1 . d-1 was given ig on d 6-12 of pregnancy in rats caused the body weight and the length of fetuses and the placental weight value significantly lower than those of the control. Thus, ischemia due to the vasoconstrictor effect is probably of great, and sometimes of supreme, importance. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:162205 |
| WOS记录号 | WOS:A1991FB87500023 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275205]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | WANG, WC |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | WANG, WC,YOU, GD,JIANG, XJ,et al. ENDOCRINE ACTIVITY OF PSEUDOLARIC ACID-A AND PSEUDOLARIC ACID-B AND THEIR EFFECTS ON SEX-HORMONES, PROSTAGLANDINS, UTERI, AND FETUSES[J]. ACTA PHARMACOLOGICA SINICA,1991,12(2):187-190. |
| APA | WANG, WC,YOU, GD,JIANG, XJ,LU, RF,&GU, ZP.(1991).ENDOCRINE ACTIVITY OF PSEUDOLARIC ACID-A AND PSEUDOLARIC ACID-B AND THEIR EFFECTS ON SEX-HORMONES, PROSTAGLANDINS, UTERI, AND FETUSES.ACTA PHARMACOLOGICA SINICA,12(2),187-190. |
| MLA | WANG, WC,et al."ENDOCRINE ACTIVITY OF PSEUDOLARIC ACID-A AND PSEUDOLARIC ACID-B AND THEIR EFFECTS ON SEX-HORMONES, PROSTAGLANDINS, UTERI, AND FETUSES".ACTA PHARMACOLOGICA SINICA 12.2(1991):187-190. |
入库方式： OAI收割
来源：上海药物研究所
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