WHOLE-BODY AUTORADIOGRAPHIC LOCALIZATION OF DIMERCAPTOSUCCINIC ACID PER-OS IN MICE
文献类型：期刊论文
| 作者 | LIANG, YY; ZHANG, JS |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-03 |
| 卷号 | 12期号:2页码:191-& |
| 关键词 | DIMERCAPTOSUCCINIC ACID TISSUE DISTRIBUTION AUTORADIOGRAPHY |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | Dimercapto [C-14]succinic acid ([C-14]DMSA) was given to male mice by ig 233 kBq. The mice were sacrificed by immersion in dry ice/hexane at 1, 3, 9 and 24 h. The distribution and concentration of [C-14]DMSA were observed and analysed by whole-body autoradiograph. Higher concentration appeared in oral cavity, esophagus, gastrointestinal contents, liver, kidney and urine at 1 or 3 h. A moderate concentration was seen in blood, bone and skin. A remarkable reduction of radioactivity was found in liver at 9 h, but GI contents, Harderian gland, kidney and urine retained intense distribution. The results indicated that DMSA absorbed rapidly per os and was eliminated by kidney within 24 h. No tissue had a pronounced retention of the [C-14]DMSA. |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| CSCD记录号 | CSCD:162206 |
| WOS记录号 | WOS:A1991FB87500024 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275206]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | LIANG, YY |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | LIANG, YY,ZHANG, JS. WHOLE-BODY AUTORADIOGRAPHIC LOCALIZATION OF DIMERCAPTOSUCCINIC ACID PER-OS IN MICE[J]. ACTA PHARMACOLOGICA SINICA,1991,12(2):191-&. |
| APA | LIANG, YY,&ZHANG, JS.(1991).WHOLE-BODY AUTORADIOGRAPHIC LOCALIZATION OF DIMERCAPTOSUCCINIC ACID PER-OS IN MICE.ACTA PHARMACOLOGICA SINICA,12(2),191-&. |
| MLA | LIANG, YY,et al."WHOLE-BODY AUTORADIOGRAPHIC LOCALIZATION OF DIMERCAPTOSUCCINIC ACID PER-OS IN MICE".ACTA PHARMACOLOGICA SINICA 12.2(1991):191-&. |
入库方式： OAI收割
来源：上海药物研究所
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