EFFECTS OF TETRAHYDROPROTOBERBERINES ON DOPAMINE RELEASE AND 3,4-DIHYDROXYPHENYLACETIC ACID LEVEL IN CORPUS STRIATUM MEASURED BY INVIVO VOLTAMMETRY
文献类型：期刊论文
| 作者 | HUANG, KX; SUN, BC; GONON, FG; JIN, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1991-01 |
| 卷号 | 12期号:1页码:32-36 |
| 关键词 | STEPHOLIDINE TETRAHYDROPALMATINE BERBERINES VOLTAMMETRY DOPAMINE DOPAMINE RECEPTORS 3,4-DIHYDROXYPHENYLACETIC ACID CORPUS STRIATUM |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | The extracellular (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum were measured by in vivo voltammetry to elucidate the effects of 3 tetrahydroprotoberberines on DA neurotransmission. l-tetrahydropalmatine (l- THP, 2 mg . kg-1) or l-stepholidine (l-SPD, 0.5 mg . kg-1) iv increased the striatal DA release by 225% and 233%, respectively; and l-SPD increased the DOPAC level by 70%. Moreover, the enantiomer d-THP (2 mg . kg-1) increased the DA release by 97%, and a large dose of d-THP (20 mg . kg-1) dramatically increased the extracellular DA by 1456% while it slightly elevated the DOPAC level by 123%. These results support the previous ideas that l-SPD and l-THP can block DA receptors and d-THP can deplete neuronal DA. |
| WOS关键词 | IMPULSE FLOW ; RAT STRIATUM ; TETRAHYDROPALMATINE ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 中文 |
| WOS记录号 | WOS:A1991ER55700007 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275218]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | HUANG, KX |
| 作者单位 | CNRS, UA 1195, INSERM, U171, F-69230 LYONS, FRANCE |
| 推荐引用方式 GB/T 7714 | HUANG, KX,SUN, BC,GONON, FG,et al. EFFECTS OF TETRAHYDROPROTOBERBERINES ON DOPAMINE RELEASE AND 3,4-DIHYDROXYPHENYLACETIC ACID LEVEL IN CORPUS STRIATUM MEASURED BY INVIVO VOLTAMMETRY[J]. ACTA PHARMACOLOGICA SINICA,1991,12(1):32-36. |
| APA | HUANG, KX,SUN, BC,GONON, FG,&JIN, GZ.(1991).EFFECTS OF TETRAHYDROPROTOBERBERINES ON DOPAMINE RELEASE AND 3,4-DIHYDROXYPHENYLACETIC ACID LEVEL IN CORPUS STRIATUM MEASURED BY INVIVO VOLTAMMETRY.ACTA PHARMACOLOGICA SINICA,12(1),32-36. |
| MLA | HUANG, KX,et al."EFFECTS OF TETRAHYDROPROTOBERBERINES ON DOPAMINE RELEASE AND 3,4-DIHYDROXYPHENYLACETIC ACID LEVEL IN CORPUS STRIATUM MEASURED BY INVIVO VOLTAMMETRY".ACTA PHARMACOLOGICA SINICA 12.1(1991):32-36. |
入库方式： OAI收割
来源：上海药物研究所
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