BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE
文献类型：期刊论文
| 作者 | LI, XY |
| 刊名 | MEMORIAS DO INSTITUTO OSWALDO CRUZ
 |
| 出版日期 | 1991 |
| 卷号 | 86页码:31-37 |
| 关键词 | FRUCTUS-SCHIZANDRAE SCHIZANDRACEAE DIBENZOCYCLOOCTENE NEOLIGNANS HEPATOPROTECTIVE AGENTS DDB |
| ISSN号 | 0074-0276 |
| DOI | 10.1590/S0074-02761991000600010 |
| 文献子类 | Article; Proceedings Paper |
| 英文摘要 | Fructus Schisandrae sinensis Baill, a traditional Chinese medicine, used as tonic and sedative, has been shown at the beginning of 70's to lower the elevated serum glutamic-pyruvic transaminase (SGPT) levels of patients suffering from chronic viral hepatitis. During past 20 years, a series of neolignans have been isolated and identified as effective principles. Pharmacological studies revealed that they increased liver protein and glycogen synthesis, antagonized liver injuries from CCl4 and thioacetamide. The mechanism of SGPT lowering was considered as a hepato-protective and membrane stabilize action, although inhibition of the activity of liver GPT may also be existed. It was found that some principles of Schisandrae have an inducing effect on hepatic microsomal drug-metabolizing enzyme system P-450, thus explained their anti-toxic, anti-carcinogenic and anti-mutagenic effects. A synthetic derivative compound of Schisandrin called DDB has most of the above mentioned actions now used widely in China as a hepato-protective drug with high effectiveness in normalizing liver functions and very low side effects. From natural Schisandrin to synthesized DDB, pointed out a successful way in the development of new drugs from natural products. |
| WOS关键词 | PHARMACOLOGICAL PROPERTIES ; METABOLISM ; CHINENSIS |
| WOS研究方向 | Parasitology ; Tropical Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:A1991GN58900010 |
| 出版者 | MEM INST OSWALDO CRUZ |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275222]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | LI, XY |
| 作者单位 | CHINESE ACAD SCI,SHANGHAI INST MAT MED,319 YUE YANG RD,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | LI, XY. BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE[J]. MEMORIAS DO INSTITUTO OSWALDO CRUZ,1991,86:31-37. |
| APA | LI, XY.(1991).BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE.MEMORIAS DO INSTITUTO OSWALDO CRUZ,86,31-37. |
| MLA | LI, XY."BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE".MEMORIAS DO INSTITUTO OSWALDO CRUZ 86(1991):31-37. |
入库方式： OAI收割
来源：上海药物研究所
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