中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE

文献类型:期刊论文

作者LI, XY
刊名MEMORIAS DO INSTITUTO OSWALDO CRUZ
出版日期1991
卷号86页码:31-37
关键词FRUCTUS-SCHIZANDRAE SCHIZANDRACEAE DIBENZOCYCLOOCTENE NEOLIGNANS HEPATOPROTECTIVE AGENTS DDB
ISSN号0074-0276
DOI10.1590/S0074-02761991000600010
文献子类Article; Proceedings Paper
英文摘要Fructus Schisandrae sinensis Baill, a traditional Chinese medicine, used as tonic and sedative, has been shown at the beginning of 70's to lower the elevated serum glutamic-pyruvic transaminase (SGPT) levels of patients suffering from chronic viral hepatitis. During past 20 years, a series of neolignans have been isolated and identified as effective principles. Pharmacological studies revealed that they increased liver protein and glycogen synthesis, antagonized liver injuries from CCl4 and thioacetamide. The mechanism of SGPT lowering was considered as a hepato-protective and membrane stabilize action, although inhibition of the activity of liver GPT may also be existed. It was found that some principles of Schisandrae have an inducing effect on hepatic microsomal drug-metabolizing enzyme system P-450, thus explained their anti-toxic, anti-carcinogenic and anti-mutagenic effects. A synthetic derivative compound of Schisandrin called DDB has most of the above mentioned actions now used widely in China as a hepato-protective drug with high effectiveness in normalizing liver functions and very low side effects. From natural Schisandrin to synthesized DDB, pointed out a successful way in the development of new drugs from natural products.
WOS关键词PHARMACOLOGICAL PROPERTIES ; METABOLISM ; CHINENSIS
WOS研究方向Parasitology ; Tropical Medicine
语种英语
WOS记录号WOS:A1991GN58900010
出版者MEM INST OSWALDO CRUZ
源URL[http://119.78.100.183/handle/2S10ELR8/275222]  
专题中国科学院上海药物研究所
通讯作者LI, XY
作者单位CHINESE ACAD SCI,SHANGHAI INST MAT MED,319 YUE YANG RD,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式
GB/T 7714
LI, XY. BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE[J]. MEMORIAS DO INSTITUTO OSWALDO CRUZ,1991,86:31-37.
APA LI, XY.(1991).BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE.MEMORIAS DO INSTITUTO OSWALDO CRUZ,86,31-37.
MLA LI, XY."BIOACTIVITY OF NEOLIGNANS FROM FRUCTUS SCHIZANDRAE".MEMORIAS DO INSTITUTO OSWALDO CRUZ 86(1991):31-37.

入库方式: OAI收割

来源:上海药物研究所

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