中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA

文献类型:期刊论文

作者XU, B
刊名MEMORIAS DO INSTITUTO OSWALDO CRUZ
出版日期1991
卷号86页码:51-54
关键词ANTICANCER AGENTS HYDROXYCAMPTOTHECIN HOMOHARRINGTONINE LYCOBETAINE OXALYSINE
ISSN号0074-0276
DOI10.1590/S0074-02761991000600014
文献子类Article; Proceedings Paper
英文摘要In this paper a number of anticancer agents of natural origin will be presented. Hydroxycamptothecin (HCPT) was found to produce a strong inhibitory action on a variety of animal tumors. It is also effective for treatment of patients with gastric carcinoma, liver carcinoma, tumor of head and neck or leukemia. Pharmacologic studies showed that it could depress S phase of tumor cells significantly and cause formation of cellular chromatid breaks. By means of alkaline elution and nick translation methods it has been proved that HCPT induced DNA single strand breaks remarkably. Homoharringtonine (HHRT) was shown to be effective against acute leukemia. Recent experiments in tumor-bearing mice indicated that (HHRT) could diminish tumor metastasis. Using molecular hybridization technique it was demonstrated that (HHRT) decreased the content of c-myc RNA in the cytoplasm but not in the nuclei. Lycobetaine (LBT) possessed strong inhibitory effects on a number of ascites tumors. In clinical trials it was effective against ovarian and gastric carcinomas. It is able to intercalate into DNA. Oxalysine (OXL) is a new antibiotic and shown to be effective against tumor metastatis. When used in combination with 5-FU, its anticancer action could be enhanced. Other natural compounds such as indirubin, beta-elemene, irisquinone, oridonine, norcantharidin and PSP have been also found to possess antitumor action.
WOS研究方向Parasitology ; Tropical Medicine
语种英语
WOS记录号WOS:A1991GN58900014
出版者MEM INST OSWALDO CRUZ
源URL[http://119.78.100.183/handle/2S10ELR8/275223]  
专题中国科学院上海药物研究所
通讯作者XU, B
作者单位CHINESE ACAD SCI,SHANGAI INST MAT MED,319 YUE YANG RD,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式
GB/T 7714
XU, B. RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA[J]. MEMORIAS DO INSTITUTO OSWALDO CRUZ,1991,86:51-54.
APA XU, B.(1991).RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA.MEMORIAS DO INSTITUTO OSWALDO CRUZ,86,51-54.
MLA XU, B."RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA".MEMORIAS DO INSTITUTO OSWALDO CRUZ 86(1991):51-54.

入库方式: OAI收割

来源:上海药物研究所

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