RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA
文献类型：期刊论文
| 作者 | XU, B
|
| 刊名 | MEMORIAS DO INSTITUTO OSWALDO CRUZ
 |
| 出版日期 | 1991 |
| 卷号 | 86页码:51-54 |
| 关键词 | ANTICANCER AGENTS HYDROXYCAMPTOTHECIN HOMOHARRINGTONINE LYCOBETAINE OXALYSINE |
| ISSN号 | 0074-0276 |
| DOI | 10.1590/S0074-02761991000600014 |
| 文献子类 | Article; Proceedings Paper |
| 英文摘要 | In this paper a number of anticancer agents of natural origin will be presented. Hydroxycamptothecin (HCPT) was found to produce a strong inhibitory action on a variety of animal tumors. It is also effective for treatment of patients with gastric carcinoma, liver carcinoma, tumor of head and neck or leukemia. Pharmacologic studies showed that it could depress S phase of tumor cells significantly and cause formation of cellular chromatid breaks. By means of alkaline elution and nick translation methods it has been proved that HCPT induced DNA single strand breaks remarkably. Homoharringtonine (HHRT) was shown to be effective against acute leukemia. Recent experiments in tumor-bearing mice indicated that (HHRT) could diminish tumor metastasis. Using molecular hybridization technique it was demonstrated that (HHRT) decreased the content of c-myc RNA in the cytoplasm but not in the nuclei. Lycobetaine (LBT) possessed strong inhibitory effects on a number of ascites tumors. In clinical trials it was effective against ovarian and gastric carcinomas. It is able to intercalate into DNA. Oxalysine (OXL) is a new antibiotic and shown to be effective against tumor metastatis. When used in combination with 5-FU, its anticancer action could be enhanced. Other natural compounds such as indirubin, beta-elemene, irisquinone, oridonine, norcantharidin and PSP have been also found to possess antitumor action. |
| WOS研究方向 | Parasitology ; Tropical Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:A1991GN58900014 |
| 出版者 | MEM INST OSWALDO CRUZ |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275223]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | XU, B |
| 作者单位 | CHINESE ACAD SCI,SHANGAI INST MAT MED,319 YUE YANG RD,SHANGHAI 200031,PEOPLES R CHINA. |
| 推荐引用方式 GB/T 7714 | XU, B. RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA[J]. MEMORIAS DO INSTITUTO OSWALDO CRUZ,1991,86:51-54. |
| APA | XU, B.(1991).RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA.MEMORIAS DO INSTITUTO OSWALDO CRUZ,86,51-54. |
| MLA | XU, B."RECENT ADVANCES IN PHARMACOLOGICAL STUDY OF NATURAL ANTICANCER AGENTS IN CHINA".MEMORIAS DO INSTITUTO OSWALDO CRUZ 86(1991):51-54. |
入库方式： OAI收割
来源：上海药物研究所
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