PENTOBARBITAL SELECTIVELY BLOCKS SUPRASPINAL MORPHINE ANALGESIA - EVIDENCE FOR GABA-A RECEPTOR INVOLVEMENT
文献类型：期刊论文
| 作者 | DING, XH; JI, XQ; TSOU, K |
| 刊名 | PAIN
 |
| 出版日期 | 1990-12 |
| 卷号 | 43期号:3页码:371-376 |
| 关键词 | ANALGESIA MORPHINE PENTOBARBITAL GABA-A RECEPTOR |
| ISSN号 | 0304-3959 |
| 文献子类 | Article |
| 英文摘要 | The possibility that the GABA(A) receptor is involved in supraspinal morphine analgesia was investigated in rats using pentobarbital and other GABA(A) receptor-chloride channel ligands. Inhibition of tail-flick was used as an index of analgesia. Pentobarbital almost completely reversed intracerebroventricular (i.c.v.) morphine analgesia, but did not affect intrathecal (i.t.) morphine analgesia. Phenobarbital had a similar effect but was much weaker. Picrotoxin blocked the reversal effect of pentobarbital. Diazepam, when given together with pentobarbital, enhanced the effect of pentobarbital. Furthermore, muscimol reversed i.c.v. morphine analgesia without affecting i.t. morphine analgesia. Our results strongly suggest that the GABA(A) receptor is involved in supraspinal morphine analgesia. |
| WOS关键词 | CULTURED MAMMALIAN NEURONS ; RATS ; PATHWAYS ; PEPTIDES |
| WOS研究方向 | Anesthesiology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:A1990EP10800012 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275229]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | CHINESE ACAD SCI, SHANGHAI INST MAT MED, SHANGHAI 200031, PEOPLES R CHINA |
| 推荐引用方式 GB/T 7714 | DING, XH,JI, XQ,TSOU, K. PENTOBARBITAL SELECTIVELY BLOCKS SUPRASPINAL MORPHINE ANALGESIA - EVIDENCE FOR GABA-A RECEPTOR INVOLVEMENT[J]. PAIN,1990,43(3):371-376. |
| APA | DING, XH,JI, XQ,&TSOU, K.(1990).PENTOBARBITAL SELECTIVELY BLOCKS SUPRASPINAL MORPHINE ANALGESIA - EVIDENCE FOR GABA-A RECEPTOR INVOLVEMENT.PAIN,43(3),371-376. |
| MLA | DING, XH,et al."PENTOBARBITAL SELECTIVELY BLOCKS SUPRASPINAL MORPHINE ANALGESIA - EVIDENCE FOR GABA-A RECEPTOR INVOLVEMENT".PAIN 43.3(1990):371-376. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。