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Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis

文献类型：期刊论文

作者Hu, Hongli2; Zhu, Wenwei3,4,5; Qin, Jun6,7; Chen, Min2; Gong, Liyan2; Li, Long2; Liu, Xiangyuan2; Tao, Yongzhen8; Yin, Huiyong8; Zhou, Hu
刊名HEPATOLOGY
出版日期2017-02
卷号65期号:2页码:515-528
ISSN号0270-9139
DOI10.1002/hep.28887
文献子类Article
英文摘要Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues and a negative correlation between PGK1 expression and liver cancer patient survival. Furthermore, depletion of PGK1 dramatically reduced cancer cell proliferation and tumorigenesis, indicating an oncogenic role of PGK1 in liver cancer progression. Moreover, we identified acetylation at the K323 site of PGK1 as an important regulatory mechanism for promoting its enzymatic activity and cancer cell metabolism. And we further characterized P300/cyclic adenosine monophosphate response element binding protein-binding protein-associated factor (PCAF) and Sirtuin 7 as the enzymes regulating K323 acetylation from both directions in liver cancer cells. Conclusion: These findings demonstrate a novel regulation of PGK1 as well as its important role in liver cancer progression.
WOS关键词PHOSPHOGLYCERATE KINASE ; HEPATOCELLULAR-CARCINOMA ; PYRUVATE-KINASE ; TUMOR-GROWTH ; METABOLISM ; EXPRESSION ; TRANSCRIPTION ; GLYCOLYSIS ; MUTATIONS ; ISOFORM
资助项目Ministry of Science and Technology of China[2015CB964502] ; National Natural Science foundation of China[81372602] ; National Natural Science foundation of China[81422033]
WOS研究方向Gastroenterology & Hepatology
语种英语
出版者WILEY
WOS记录号WOS:000397300700014
源URL[http://119.78.100.183/handle/2S10ELR8/275644]  
专题中国科学院上海药物研究所
通讯作者Gao, Daming
作者单位1.Fudan Univ, Coll Life Sci, Shanghai Med Coll, Key Lab Mol Med Minist Educ, Shanghai, Peoples R China;
2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Innovat Ctr Cell Signaling Network, CAS Key Lab Syst Biol,Shanghai Inst Biol Sci,Inst, Shanghai, Peoples R China;
3.Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai, Peoples R China;
4.Fudan Univ, Inst Biomed Sci, Liver Canc Inst, Shanghai, Peoples R China;
5.Fudan Univ, Zhongshan Hosp, Inst Biomed Sci, Shanghai, Peoples R China;
6.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China;
7.Shanghai Jiao Tong Univ Sch Med, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai, Peoples R China;
8.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutrit Sci, Key Lab Food Safety Res, Shanghai, Peoples R China;
9.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China;
10.Fudan Univ, Coll Life Sci, Shanghai Med Coll, Inst Biomed Sci, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Hongli,Zhu, Wenwei,Qin, Jun,et al. Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis[J]. HEPATOLOGY,2017,65(2):515-528.
APA Hu, Hongli.,Zhu, Wenwei.,Qin, Jun.,Chen, Min.,Gong, Liyan.,...&Gao, Daming.(2017).Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis.HEPATOLOGY,65(2),515-528.
MLA Hu, Hongli,et al."Acetylation of PGK1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis".HEPATOLOGY 65.2(2017):515-528.

入库方式： OAI收割

来源：上海药物研究所

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