Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice
文献类型：期刊论文
| 作者 | Zhang, Qian2; Hu, Minghua3,4; Xu, Lu2; Yang, Xiangliang2; Chang, Yung1; Zhu, Yanhong2 |
| 刊名 | FOOD AND AGRICULTURAL IMMUNOLOGY
 |
| 出版日期 | 2017 |
| 卷号 | 28期号:6页码:981-992 |
| 关键词 | Lentinan tremellan pachymaran influenza virus immune |
| ISSN号 | 0954-0105 |
| DOI | 10.1080/09540105.2017.1323326 |
| 文献子类 | Article |
| 英文摘要 | Fungal polysaccharides have shown broad spectrum of biological activities, including anti-inflammatory, ant-oxidative and improve immunity. However, oral administration of fungal polysaccharides for rendering the conventional vaccine against influenza virus has been reported rarely. Here, we investigated the potential of fungal polysaccharides in enhancing the influenza vaccine efficacy in a mouse model. Mice were immunized with inactivated H1N1 (A/PR8/1934) influenza vaccine combined with oral polysaccharides lentinan, tremellan, pachymaran and a mixture of the three. The results showed that mice in the polysaccharides/vaccine groups had reduced morbidity, improved viral clearance, and recovered faster than the mice receiving the conventional vaccine only after infection. This effect could be attributed to the increased levels of virus-specific serum antibody IgG and decreased levels of inflammatory cytokine IFN-gamma in the lung tissue. Our finding suggests that taking fungal polysaccharides orally might be useful for improving the efficacy of conventional inactive influenza vaccines. |
| WOS关键词 | T-CELLS ; HOHENBUEHELIA-SEROTINA ; ANTIOXIDANT ACTIVITY ; PANDEMIC INFLUENZA ; CYTOKINE STORM ; VIRUS ; IMMUNITY ; IMMUNIZATION ; MUSHROOMS ; INFECTION |
| 资助项目 | Natural Science Foundation of Hubei Province[2015CFA041] |
| WOS研究方向 | Chemistry ; Food Science & Technology ; Immunology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000410806400005 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275698]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, Yanhong |
| 作者单位 | 1.Arizona State Univ, Biodesign Inst, Ctr Infect Dis & Vaccinol, Tempe, AZ USA 2.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, 1037 Luoyu Rd, Wuhan 430074, Hubei, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Joint Lab Res Chinese Herbal Polysaccharides, Shanghai, Peoples R China; 4.Infinitus, Shanghai, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, Qian,Hu, Minghua,Xu, Lu,et al. Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2017,28(6):981-992. |
| APA | Zhang, Qian,Hu, Minghua,Xu, Lu,Yang, Xiangliang,Chang, Yung,&Zhu, Yanhong.(2017).Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice.FOOD AND AGRICULTURAL IMMUNOLOGY,28(6),981-992. |
| MLA | Zhang, Qian,et al."Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice".FOOD AND AGRICULTURAL IMMUNOLOGY 28.6(2017):981-992. |
入库方式： OAI收割
来源：上海药物研究所
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