Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions
文献类型：期刊论文
| 作者 | Yu, Yang2,3; Mang, Zhiguo2,3; Yang, Wei1; Li, Hao2,3; Wang, Wei2,3,4 |
| 刊名 | CATALYSTS
 |
| 出版日期 | 2016-11 |
| 卷号 | 6期号:11 |
| 关键词 | Pd(TFA)(2) [4+1] annulation alpha-alkenyl-dicarbonyl compounds unprotected primary amines one-pot tandem reaction regio-selective |
| ISSN号 | 2073-4344 |
| DOI | 10.3390/catal6110169 |
| 文献子类 | Article |
| 英文摘要 | The Pd(TFA)(2)-catalyzed [4+1] annulation of chained or cyclic alpha-alkenyl-dicarbonyl compounds and unprotected primary amines for "one-pot" synthesis of pyrroles is reported here. Enamination and amino-alkene were involved in this practical and efficient tandem reaction. The annulation products were isolated in moderate to excellent yields with O-2 as the terminal oxidant under mild conditions. In addition, this method was applied to synthesize highly regioselective aminomethylated and di(1H-pyrrol-3-yl) methane products. |
| WOS关键词 | N BOND FORMATION ; WACKER-TYPE CYCLIZATION ; C-H AMIDATION ; ATORVASTATIN CALCIUM ; SUBSTITUTED PYRROLES ; OXIDATIVE AMINATION ; EFFICIENT SYNTHESIS ; 3+2 CYCLOADDITION ; DERIVATIVES ; ALKENES |
| 资助项目 | National Science Foundation of China[21372073] ; National Science Foundation of China[21572054] ; National Science Foundation of China[21572055] ; Fundamental Research Funds for the Central Universities[00000000] ; China 111 Project[B07023] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000388371400004 |
| 出版者 | MDPI AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275830]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Hao; Wang, Wei |
| 作者单位 | 1.Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China; 3.East China Univ Sci & Technol, Sch Pharm, 130 Mei Long Rd, Shanghai 200237, Peoples R China; 4.Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA |
| 推荐引用方式 GB/T 7714 | Yu, Yang,Mang, Zhiguo,Yang, Wei,et al. Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions[J]. CATALYSTS,2016,6(11). |
| APA | Yu, Yang,Mang, Zhiguo,Yang, Wei,Li, Hao,&Wang, Wei.(2016).Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions.CATALYSTS,6(11). |
| MLA | Yu, Yang,et al."Practical Pd(TFA)(2)-Catalyzed Aerobic [4+1] Annulation for the Synthesis of Pyrroles via "One-Pot" Cascade Reactions".CATALYSTS 6.11(2016). |
入库方式： OAI收割
来源：上海药物研究所
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