Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions
文献类型：期刊论文
| 作者 | Wu, Xu1,2,3; Ma, Jiang1,2,3; Ye, Yang1,3,4 ; Lin, Ge1,2,3
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| 刊名 | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
 |
| 出版日期 | 2016-07-15 |
| 卷号 | 1026页码:236-253 |
| 关键词 | Herb-drug interaction Solute carrier transporter ATP-binding cassette transporter Chinese herbal medicines Natural products |
| ISSN号 | 1570-0232 |
| DOI | 10.1016/j.jchromb.2015.11.024 |
| 文献子类 | Article |
| 英文摘要 | The increasing use of Chinese herbal medicines (CHMs) as complementary therapy and dietary supplement has been greatly raising the concerns about potential herb-drug interactions (HDIs). HDIs may cause the augmented or antagonized effects of prescription drugs, resulting in unexpected clinical outcomes. Therefore, it is of significance to identify or predict potential HDIs, and to delineate the underlying mechanisms. Drug transporters play key roles in transmembrane passage of a large number of drugs, affecting their absorption, distribution and elimination. Modulation of drug transporters has been recognized as one of the main causes of HDIs. In the last decade, a growing number of Chinese medicinal herbs and their derived phytochemicals have been identified to have modulatory effect toward transporter proteins, leading to pharmacokinetic HDIs when concomitantly used with conventional drugs. Some of these transporter-mediated interactions have already shown clinical significance. This review article focuses on two major transporter superfamilies, the solute carrier (SLC) and the ATP-binding cassette (ABC) transporters, to provide the recent advanced knowledge on CHMs and their inherent phytochemicals that interact with these transporters, and their induced pharmacokinetic HDIs from both preclinical and clinical aspects. In addition, the challenges and strategy for studying HDIs are also discussed. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS关键词 | SCHISANDRA-SPHENANTHERA-EXTRACT ; P-GLYCOPROTEIN EXPRESSION ; GINKGO-BILOBA EXTRACT ; PREGNANE X RECEPTOR ; BLOOD-BRAIN-BARRIER ; SALVIA-MILTIORRHIZA BUNGE ; RESISTANCE-ASSOCIATED PROTEIN-1 ; SOLUTE CARRIER TRANSPORTERS ; MAJOR ACTIVE CONSTITUENT ; BREAST-CANCER CELLS |
| 资助项目 | CUHK School of Biomedical Sciences-Seed Fund for Joint Establishments[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000379636800026 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/275957]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lin, Ge |
| 作者单位 | 1.Chinese Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China; 2.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Joint Res Lab Promoting Globalizat Tradit Chinese, Hong Kong, Hong Kong, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Xu,Ma, Jiang,Ye, Yang,et al. Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions[J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,2016,1026:236-253. |
| APA | Wu, Xu,Ma, Jiang,Ye, Yang,&Lin, Ge.(2016).Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions.JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,1026,236-253. |
| MLA | Wu, Xu,et al."Transporter modulation by Chinese herbal medicines and its mediated pharmacokinetic herb-drug interactions".JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 1026(2016):236-253. |
入库方式： OAI收割
来源：上海药物研究所
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