3D visualization of the lumbar facet joint after degeneration using propagation phase contrast microtomography
文献类型：期刊论文
| 作者 | Cao, Yong2; Zhang, Yi2; Yin, Xianzheng1; Lu, Hongbin3; Hu, Jianzhong2; Duan, Chunyue2 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-02-24 |
| 卷号 | 6 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep21838 |
| 文献子类 | Article |
| 英文摘要 | Lumbar facet joint (LFJ) degeneration is believed to be an important cause of low back pain (LBP). Identifying the morphological changes of the LFJ in the degeneration process at a high-resolution level could be meaningful for our better understanding of the possible mechanisms underlying this process. In the present study, we determined the 3D morphology of the LFJ using propagation phase contrast micro-tomography (PPCT) in rats to assess the subtle changes that occur during the degeneration process. PPCT provides vivid 3D images of micromorphological changes in the LFJ during its degeneration process, and the changes in the subchondral bone occurred earlier than in the cartilage during the early stage of degeneration of the LFJ. The delineation of this alteration was similar to that with the histological method. Our findings demonstrated that PPCT could serve as a valuable tool for 3D visualization of the morphology of the LFJ by providing comprehensive information about the cartilage and the underlying subchondral bone and their changes during degeneration processes. It might also have great potential for providing effective diagnostic tools to track changes in the cartilage and to evaluate the effects of therapeutic interventions for LFJ degeneration in preclinical studies. |
| WOS关键词 | SYNCHROTRON-RADIATION ; COMPUTED-TOMOGRAPHY ; INTRAARTICULAR INJECTION ; SUBCHONDRAL PLATE ; SPINAL-CORD ; BACK-PAIN ; RAT MODEL ; X-RAYS ; OSTEOARTHRITIS ; THICKNESS |
| 资助项目 | National Natural Science Foundation of China[81301522] ; National Natural Science Foundation of China[81371956] ; Hunan Provincial Innovation Foundation For Postgraduate[CX2015B060] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000370682500001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276136]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Jianzhong; Duan, Chunyue |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China; 2.Cent S Univ, Xiangya Hosp, Dept Spine Surg, Changsha 410008, Hunan, Peoples R China; 3.Cent S Univ, Xiangya Hosp, Res Ctr Sports Med, Dept Sports Med, Changsha 410008, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Yong,Zhang, Yi,Yin, Xianzheng,et al. 3D visualization of the lumbar facet joint after degeneration using propagation phase contrast microtomography[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Cao, Yong,Zhang, Yi,Yin, Xianzheng,Lu, Hongbin,Hu, Jianzhong,&Duan, Chunyue.(2016).3D visualization of the lumbar facet joint after degeneration using propagation phase contrast microtomography.SCIENTIFIC REPORTS,6. |
| MLA | Cao, Yong,et al."3D visualization of the lumbar facet joint after degeneration using propagation phase contrast microtomography".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：上海药物研究所
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