Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor
文献类型：期刊论文
| 作者 | Zeng Feng1,2; Pan Zhenzhen1,2; Zhang Meng1; Huang Yongzhuo1 ; Cui Yanna1; Xu Qin2
|
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2015-10 |
| 卷号 | 27期号:10页码:1356-1373 |
| 关键词 | ordered mesoporous structure silica nanoparticles synthesis and modification tumor diagnosis and therapy |
| ISSN号 | 1005-281X |
| DOI | 10.7536/PC150437 |
| 文献子类 | Review |
| 英文摘要 | Ordered mesoporous silica nanoparticles (MSNs) have drawn a great deal of attention in the biomedical fields because of their specific structures and unique physical chemistry properties. Combined with various functional materials or molecules, such as magnetic nanoparticles, fluorescent probes, antineoplastic drugs and targeting ligands, ordered mesoporous silica nanoparticles can be developed into the multifunctional nanomedicines in the application of diagnosis and therapy of tumor. The recent progress on synthetic methods, surface modification and application of MSNs are reviewed. First of all, the methods of synthesis in different pH medium and template removal are summarized in detail along with a brief introduction on their merits and drawbacks. Secondly, surface modification methods are described, including surface stabilization and surface functionalization. Thirdly, the application progress of targeted therapy and imaging diagnosis of MSNs loaded with imaging agents or chemotherapy drugs are also concluded. The final part outlines the challenges and perspectives. |
| WOS关键词 | TARGETED DRUG-DELIVERY ; IN-VIVO ; COLLOIDAL SUSPENSIONS ; MULTIDRUG-RESISTANCE ; ORGANIC TEMPLATES ; SPHERICAL MCM-48 ; POROUS MATERIALS ; CANCER-THERAPY ; PARTICLE-SIZE ; THIN-FILMS |
| 资助项目 | National Natural Science Foundation of China[81402885] ; Chinese Postdoctoral Science Foundation[2014M551475] |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:5590821 |
| WOS记录号 | WOS:000364260900003 |
| 出版者 | CHINESE ACAD SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276378]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cui Yanna |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China; 2.Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng Feng,Pan Zhenzhen,Zhang Meng,et al. Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor[J]. PROGRESS IN CHEMISTRY,2015,27(10):1356-1373. |
| APA | Zeng Feng,Pan Zhenzhen,Zhang Meng,Huang Yongzhuo,Cui Yanna,&Xu Qin.(2015).Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor.PROGRESS IN CHEMISTRY,27(10),1356-1373. |
| MLA | Zeng Feng,et al."Preparation and Application of Ordered Mesoporous Silica Nanoparticles in the Therapy and Diagnosis of Tumor".PROGRESS IN CHEMISTRY 27.10(2015):1356-1373. |
入库方式： OAI收割
来源：上海药物研究所
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