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Structural mechanisms of RNA recognition: sequence-specific and non-specific RNA-binding proteins and the Cas9-RNA-DNA complex

文献类型：期刊论文

作者Ban, Ting2,3,4; Zhu, Jian-Kang3,4,5; Melcher, Karsten1,6; Xu, H. Eric1,2,6
刊名CELLULAR AND MOLECULAR LIFE SCIENCES
出版日期2015-03
卷号72期号:6页码:1045-1058
ISSN号1420-682X
关键词RNA recognition RNA-binding protein Tandem repeat module Sequence-specific recognition Protein-protein interaction
DOI10.1007/s00018-014-1779-9
文献子类Review
英文摘要RNA-binding proteins play crucial roles in RNA processing and function as regulators of gene expression. Recent studies have defined the structural basis for RNA recognition by diverse RNA-binding motifs. While many RNA-binding proteins recognize RNA sequence non-specifically by associating with 5' or 3' RNA ends, sequence-specific recognition by RNA-binding proteins is typically achieved by combining multiple modular domains to form complex binding surfaces. In this review, we present examples of structures from different classes of RNA-binding proteins, identify the mechanisms utilized by them to target specific RNAs, and describe structural principles of how protein-protein interactions affect RNA recognition specificity. We also highlight the structural mechanism of sequence-dependent and -independent interactions in the Cas9-RNA-DNA complex.
WOS关键词PENTATRICOPEPTIDE REPEAT PROTEINS ; PUMILIO-HOMOLOGY DOMAIN ; CRYSTAL-STRUCTURE ; MODULAR RECOGNITION ; MESSENGER-RNA ; TARGET DNA ; GUIDE RNA ; REVEALS ; CAS9 ; PHOSPHORYLATION
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者SPRINGER BASEL AG
WOS记录号WOS:000350303300002
源URL[http://119.78.100.183/handle/2S10ELR8/276622]  
专题中国科学院上海药物研究所
通讯作者Ban, Ting
作者单位1.Van Andel Res Inst, Lab Struct Sci, Grand Rapids, MI 49503 USA;
2.Chinese Acad Sci, VARI SIMM Ctr, Ctr Struct & Funct Drug Targets, Key Lab Receptor Res,Shanghai Inst Mat Med, Shanghai 201203, Peoples R China;
3.Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Shanghai 200032, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Plant Physiol & Ecol, Shanghai 200032, Peoples R China;
5.Purdue Univ, Dept Hort & Landscape Architecture, W Lafayette, IN 47906 USA;
6.Van Andel Res Inst, Lab Struct Biol & Biochem, Grand Rapids, MI 49503 USA
推荐引用方式
GB/T 7714		 Ban, Ting,Zhu, Jian-Kang,Melcher, Karsten,et al. Structural mechanisms of RNA recognition: sequence-specific and non-specific RNA-binding proteins and the Cas9-RNA-DNA complex[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2015,72(6):1045-1058.
APA Ban, Ting,Zhu, Jian-Kang,Melcher, Karsten,&Xu, H. Eric.(2015).Structural mechanisms of RNA recognition: sequence-specific and non-specific RNA-binding proteins and the Cas9-RNA-DNA complex.CELLULAR AND MOLECULAR LIFE SCIENCES,72(6),1045-1058.
MLA Ban, Ting,et al."Structural mechanisms of RNA recognition: sequence-specific and non-specific RNA-binding proteins and the Cas9-RNA-DNA complex".CELLULAR AND MOLECULAR LIFE SCIENCES 72.6(2015):1045-1058.

入库方式： OAI收割

来源：上海药物研究所

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