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The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation

文献类型：期刊论文

作者Lu, Han2; Liu, Bin3; Zhang, Fu-Jun2; Zhang, Jin4; Dong, Rong2; Chen, Lei2; Qu, Dong-Mei2; Lu, Yan1; Yu, Bu-Wei2
刊名CELL CYCLE
出版日期2014-12-15
卷号13期号:24页码:3892-3902
关键词activity-dependent stimuli APC-Cdh1 MEF2A SENP2
ISSN号1538-4101
DOI10.4161/15384101.2014.973302
文献子类Article
英文摘要Activity-dependent stimuli induced a calcineurin-mediated dephosphorylation of the transcriptional factor MEF2A at serine408 and promoted a switch from SUMOylation to acetylation at lysine403 which led to MEF2A transcriptional activation. We previously identified SENP2 is the de-SUMOylation enzyme for MEF2A and promotes MEF2A-dependent transcription. We report here a requirement for APC(Cdh1)-SENP2-MEF2A axis in the regulation of MEF2A transcriptional activation. APC(Cdh1) interacts with and targets SENP2 for ubiquitination and destruction in the cytoplasm by recognizing a conserved canonical D-box motif in SENP2. Moreover, Cdh1 regulates the transcriptional activity of MEF2A in a SENP2 dependent manner. Activity-dependent stimuli prevented APC(Cdh1)-induced SENP2 ubiquitination, promoted SENP2 nuclear accumulations, and caused MEF2A de-SUMOylation and MEF2A acetylation, leading to MEF2A transcriptional activation. Thus, our findings defined a post-transcriptional mechanism underlying activity-dependent stimuli-induced MEF2A transcriptional activation.
WOS关键词ACTIVITY-DEPENDENT REGULATION ; SUMOYLATION ; MEF2 ; DESUMOYLATION ; SURVIVAL
资助项目National Natural Science Foundation, Beijing, People's Republic of China[81102513] ; National Natural Science Foundation, Beijing, People's Republic of China[81072703] ; National Natural Science Foundation, Beijing, People's Republic of China[81373492] ; Specialized Research Fund for Outstanding Young Teachers of Higher Education, Shanghai[00000000]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000348329600018
出版者LANDES BIOSCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/276799]  
专题中国科学院上海药物研究所
通讯作者Yu, Bu-Wei
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Dept Endocrine & Metab Dis,Ruijin Hosp, Shanghai Inst Endocrinol & Metab,Shanghai Clin Ct, Shanghai 200030, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Med, Dept Anesthesiol, Ruijin Hosp, Shanghai 200030, Peoples R China;
3.Hubei Polytech Univ, Coll Med, Key Lab Kidney Dis Pathogenesis & Intervent Hubei, Huangshi, Hubei, Peoples R China;
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China;
推荐引用方式
GB/T 7714		 Lu, Han,Liu, Bin,Zhang, Fu-Jun,et al. The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation[J]. CELL CYCLE,2014,13(24):3892-3902.
APA Lu, Han.,Liu, Bin.,Zhang, Fu-Jun.,Zhang, Jin.,Dong, Rong.,...&Yu, Bu-Wei.(2014).The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation.CELL CYCLE,13(24),3892-3902.
MLA Lu, Han,et al."The E3 ligase APC/C-Cdh1 regulates MEF2A-dependent transcription by targeting SUMO-specific protease 2 for ubiquitination and degradation".CELL CYCLE 13.24(2014):3892-3902.

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来源：上海药物研究所

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