Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis
文献类型：期刊论文
| 作者 | Yin, Chu-Yang2; Lin, Xiao-Lin1; Tian, Lei1; Ye, Ming1; Yang, Xin-Ying3; Xiao, Xiu-Ying1 |
| 刊名 | WORLD JOURNAL OF GASTROENTEROLOGY
 |
| 出版日期 | 2014-12-14 |
| 卷号 | 20期号:46页码:17426-17433 |
| 关键词 | Gastric cancer Lobaplatin Apoptosis |
| ISSN号 | 1007-9327 |
| DOI | 10.3748/wjg.v20.i46.17426 |
| 文献子类 | Article |
| 英文摘要 | AIM: To assess the anti-cancer effect of lobaplatin on human gastric cancer cells, and to explore the underlying molecular mechanisms. METHODS: The human gastric cancer cell lines MKN-28, AGS and MKN-45 were used. The cytotoxicity of lobaplatin was detected using an MTS cell proliferation assay. Flow cytometry was used to detect cell apoptosis using Annexin V-FITC Apoptosis Detection Kit. The expression of apoptosis-regulated genes was examined at the protein level using Western blot. RESULTS: Lobaplatin inhibited the proliferation of human gastric cancer cells and induced apoptosis, which may be associated with the up-regulation of Bax expression, poly(ADP-ribose) polymerase (PARP) cleavage, p53 expression and the reduction of Bcl-2 expression. CONCLUSION: The cytotoxicity of lobaplatin may be due to its ability of inducing apoptosis of gastric cancer cells, which would support the potential use of lobaplatin for the therapy of gastric cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. |
| WOS关键词 | ANTICANCER DRUG DEVELOPMENT ; PLATINUM ; CYCLE ; CHEMOTHERAPY |
| 资助项目 | National Natural Science Foundation of China[81101648] |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000346386300018 |
| 出版者 | BAISHIDENG PUBLISHING GROUP INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276803]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xiao, Xiu-Ying |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Ren Ji Hosp, Sch Med, Dept Oncol, Shanghai 200127, Peoples R China; 2.Fudan Univ, Obstet & Gynecol Hosp, Dept Breast Surg, Shanghai 200011, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Chu-Yang,Lin, Xiao-Lin,Tian, Lei,et al. Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2014,20(46):17426-17433. |
| APA | Yin, Chu-Yang,Lin, Xiao-Lin,Tian, Lei,Ye, Ming,Yang, Xin-Ying,&Xiao, Xiu-Ying.(2014).Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis.WORLD JOURNAL OF GASTROENTEROLOGY,20(46),17426-17433. |
| MLA | Yin, Chu-Yang,et al."Lobaplatin inhibits growth of gastric cancer cells by inducing apoptosis".WORLD JOURNAL OF GASTROENTEROLOGY 20.46(2014):17426-17433. |
入库方式： OAI收割
来源：上海药物研究所
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