SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer
文献类型：期刊论文
| 作者 | Jian, Hong1; Zhao, Yi1; Liu, Bin2; Lu, Shun1 |
| 刊名 | TUMOR BIOLOGY
 |
| 出版日期 | 2014-11 |
| 卷号 | 35期号:11页码:11051-11056 |
| 关键词 | SEMA4b Non-small cell lung cancer MMP9 ERK/MAPK PI3K JNK |
| ISSN号 | 1010-4283 |
| DOI | 10.1007/s13277-014-2409-8 |
| 文献子类 | Article |
| 英文摘要 | Semaphorin 4B (SEMA4b) has been shown to play a substantial role in the invasion of non-small cell lung cancer (NSCLC). However, the regulation mechanism of SEMA4b is largely elusive. Here, we reported significant decrease in SEMA4b level and significant increase in MMP9 level in NSCLC compared with the adjacent normal tissue from the same patient. We thus used two human NSCLC lines, A549 and Calu-3, to examine whether SEMA4b may affect the expression of MMP9 in NSCLC. We found that overexpression of SEMA4b significantly decreased MMP9 level, while SEMA4b inhibition significantly increased MMP9 level. The adapted MMP9 levels affected the potential of NSCLC invasiveness correspondingly. To define the signal transduction cascades downstream of SEMA4b for regulation of MMP9 expression, we inhibited PI3K, ERK/MAPK, or JNK signaling pathway in SEMA4b knockout NSCLC and found that only inhibition of PI3K signaling pathway significantly decreased MMP9 activation. Our data thus suggest that SEMA4b may activate PI3K signaling pathway to promote MMP9 expression, which subsequently increases metastasis of NSCLC. Our study thus highlights SEMA4b as a novel therapeutic target for NSCLC. |
| WOS关键词 | SEMAPHORIN ; ACTIVATION ; INTERACTS ; MOTILITY |
| 资助项目 | Wujieping Medical Foundation[320.6750.14060] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000345413100052 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276849]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, Shun |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Lung Canc Ctr, Shanghai Chest Hosp, Shanghai 200030, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jian, Hong,Zhao, Yi,Liu, Bin,et al. SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer[J]. TUMOR BIOLOGY,2014,35(11):11051-11056. |
| APA | Jian, Hong,Zhao, Yi,Liu, Bin,&Lu, Shun.(2014).SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer.TUMOR BIOLOGY,35(11),11051-11056. |
| MLA | Jian, Hong,et al."SEMA4b inhibits MMP9 to prevent metastasis of non-small cell lung cancer".TUMOR BIOLOGY 35.11(2014):11051-11056. |
入库方式： OAI收割
来源：上海药物研究所
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