Involvement of chromosome region maintenance 1 (CRM1) in the formation and progression of esophageal squamous cell carcinoma
文献类型：期刊论文
| 作者 | Yang, Xiaojing2,3; Cheng, Lei4; Yao, Li2; Ren, Hanru5; Zhang, Shu5; Min, Xiao6; Chen, Xueyu1; Zhang, Jianguo5; Li, Mei7 |
| 刊名 | MEDICAL ONCOLOGY
 |
| 出版日期 | 2014-09 |
| 卷号 | 31期号:9 |
| ISSN号 | 1357-0560 |
| 关键词 | Esophageal squamous cell carcinoma (ESCC) Chromosome region maintenance 1 (CRM1) Apoptosis Prognosis Chemotherapy |
| DOI | 10.1007/s12032-014-0155-9 |
| 文献子类 | Article |
| 英文摘要 | Chromosome region maintenance 1 (CRM1) has been related to several malignancies. The predictive value of CRM1 in the malignance and prognosis of esophageal squamous cell carcinoma (ESCC), however, is not clear yet. In this study, we displayed that CRM1 expression was up-regulated in ESCC using immunohistochemistry and Western blot. Statistical analysis demonstrated that patients with high CRM1 levels indicated shorter survival period. We further found that silencing CRM1 caused apoptosis in ESCC cell lines. Moreover, knockdown of CRM1 disturbed the expression of tumor suppressor proteins and inhibited NF-kappa B activity in ESCC cell lines, especially if the cell line was treated with 5-fluorouracil. In consequence, our results for the first time indicated that CRM1 was dysregulated in ESCC, and suppression of CRM1 expression which resulted in inhibiting of NF-kappa B signaling might be developed into a new strategy in ESCC therapy. |
| WOS关键词 | KAPPA-B-ALPHA ; SMALL INTERFERING RNA ; NUCLEAR EXPORT ; PROGNOSTIC VALUE ; LOW EXPRESSION ; C-MYC ; CANCER ; APOPTOSIS ; P53 ; PROLIFERATION |
| 资助项目 | Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)[00000000] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | HUMANA PRESS INC |
| WOS记录号 | WOS:000341835700028 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276919]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jianguo |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Nantong Univ, Jiangsu Prov Key Lab Inflammat & Mol Drug Target, Nantong 226001, Jiangsu, Peoples R China; 3.Shanghai Jiao Tong Univ, Dept Oncol, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China; 4.Dalian Med Univ, Affiliated Hosp 1, Dept Laparoscop Surg, Dalian 116011, Liaoning, Peoples R China; 5.Nantong Univ, Affiliated Hosp, Dept Pathol, Nantong 226001, Jiangsu, Peoples R China; 6.Shandong Univ, Natl Glycoengn Res Ctr, State Key Lab Microbial Technol, Jinan 250100, Peoples R China; 7.Nantong Univ, Affiliated Hosp, Dept Oncol, Nantong 226001, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xiaojing,Cheng, Lei,Yao, Li,et al. Involvement of chromosome region maintenance 1 (CRM1) in the formation and progression of esophageal squamous cell carcinoma[J]. MEDICAL ONCOLOGY,2014,31(9). |
| APA | Yang, Xiaojing.,Cheng, Lei.,Yao, Li.,Ren, Hanru.,Zhang, Shu.,...&Li, Mei.(2014).Involvement of chromosome region maintenance 1 (CRM1) in the formation and progression of esophageal squamous cell carcinoma.MEDICAL ONCOLOGY,31(9). |
| MLA | Yang, Xiaojing,et al."Involvement of chromosome region maintenance 1 (CRM1) in the formation and progression of esophageal squamous cell carcinoma".MEDICAL ONCOLOGY 31.9(2014). |
入库方式： OAI收割
来源：上海药物研究所
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