中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer

文献类型:期刊论文

作者Wang, Xue-Lei1; Wen, Xiao-Fei1; Li, Rong-Bing1; Liu, Bin2; Qiu, Guang-Ming1; Wen, Ji-Ling1; Wang, Yue-Min1
刊名TUMOR BIOLOGY
出版日期2014-08
卷号35期号:8页码:8143-8148
关键词Androgen receptor Prostate-specific antigen Carbohydrate-responsive element-binding protein Prostate cancer
ISSN号1010-4283
DOI10.1007/s13277-014-2085-8
文献子类Article
英文摘要Androgen receptor (AR), a member of nuclear hormone receptor, plays an essential role in the initiation and progression of prostate cancer (PCa). In the present study, by way of immunoprecipitation followed by mass spectrometry (IP/MS) system, we found that carbohydrate-responsive element-binding protein (Chrebp), a glucose sensor in normal and cancer cells, interacted with AR in LNCaP cells. The interaction was further confirmed by coimmunoprecipitation analysis. Besides, Chrebp is required for the optimal transcriptional activity of AR in promoting the transcription of the prostate-specific antigen (PSA) promoter and messenger RNA (mRNA) expression. Consistently, knockdown of Chrebp using small interfering RNA (siRNA) in LNCaP cells reduced endogenous PSA levels. Together, our study demonstrates that Chrebp interacts with AR and regulates its transcriptional activity.
WOS关键词BINDING PROTEIN CHREBP ; GLUCOSE ; PHOSPHORYLATION ; COACTIVATOR ; METABOLISM
资助项目Dongfang Zhaoyang Talent Plan[DFZY-3]
WOS研究方向Oncology
语种英语
WOS记录号WOS:000341883500107
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/276952]  
专题中国科学院上海药物研究所
通讯作者Wen, Xiao-Fei
作者单位1.Tongji Univ, Sch Med, East Hosp, Dept Urol, Shanghai 200120, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xue-Lei,Wen, Xiao-Fei,Li, Rong-Bing,et al. Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer[J]. TUMOR BIOLOGY,2014,35(8):8143-8148.
APA Wang, Xue-Lei.,Wen, Xiao-Fei.,Li, Rong-Bing.,Liu, Bin.,Qiu, Guang-Ming.,...&Wang, Yue-Min.(2014).Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer.TUMOR BIOLOGY,35(8),8143-8148.
MLA Wang, Xue-Lei,et al."Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer".TUMOR BIOLOGY 35.8(2014):8143-8148.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。