Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer
文献类型：期刊论文
| 作者 | Wang, Xue-Lei1; Wen, Xiao-Fei1; Li, Rong-Bing1; Liu, Bin2; Qiu, Guang-Ming1; Wen, Ji-Ling1; Wang, Yue-Min1 |
| 刊名 | TUMOR BIOLOGY
 |
| 出版日期 | 2014-08 |
| 卷号 | 35期号:8页码:8143-8148 |
| 关键词 | Androgen receptor Prostate-specific antigen Carbohydrate-responsive element-binding protein Prostate cancer |
| ISSN号 | 1010-4283 |
| DOI | 10.1007/s13277-014-2085-8 |
| 文献子类 | Article |
| 英文摘要 | Androgen receptor (AR), a member of nuclear hormone receptor, plays an essential role in the initiation and progression of prostate cancer (PCa). In the present study, by way of immunoprecipitation followed by mass spectrometry (IP/MS) system, we found that carbohydrate-responsive element-binding protein (Chrebp), a glucose sensor in normal and cancer cells, interacted with AR in LNCaP cells. The interaction was further confirmed by coimmunoprecipitation analysis. Besides, Chrebp is required for the optimal transcriptional activity of AR in promoting the transcription of the prostate-specific antigen (PSA) promoter and messenger RNA (mRNA) expression. Consistently, knockdown of Chrebp using small interfering RNA (siRNA) in LNCaP cells reduced endogenous PSA levels. Together, our study demonstrates that Chrebp interacts with AR and regulates its transcriptional activity. |
| WOS关键词 | BINDING PROTEIN CHREBP ; GLUCOSE ; PHOSPHORYLATION ; COACTIVATOR ; METABOLISM |
| 资助项目 | Dongfang Zhaoyang Talent Plan[DFZY-3] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000341883500107 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/276952]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wen, Xiao-Fei |
| 作者单位 | 1.Tongji Univ, Sch Med, East Hosp, Dept Urol, Shanghai 200120, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xue-Lei,Wen, Xiao-Fei,Li, Rong-Bing,et al. Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer[J]. TUMOR BIOLOGY,2014,35(8):8143-8148. |
| APA | Wang, Xue-Lei.,Wen, Xiao-Fei.,Li, Rong-Bing.,Liu, Bin.,Qiu, Guang-Ming.,...&Wang, Yue-Min.(2014).Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer.TUMOR BIOLOGY,35(8),8143-8148. |
| MLA | Wang, Xue-Lei,et al."Chrebp regulates the transcriptional activity of androgen receptor in prostate cancer".TUMOR BIOLOGY 35.8(2014):8143-8148. |
入库方式： OAI收割
来源：上海药物研究所
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