Interaction between smoking and CYP2C19*3 polymorphism increased risk of lung cancer in a Chinese population
文献类型：期刊论文
| 作者 | Yan, Fei1; Xu, Jin-Fu3; Liu, Xiao-fang2; Li, Xing-Hua1 |
| 刊名 | TUMOR BIOLOGY
 |
| 出版日期 | 2014-06 |
| 卷号 | 35期号:6页码:5295-5298 |
| 关键词 | Lung cancer Cytochrome P450 Epoxyeicosatrienoic acids Polymorphism Smoking |
| ISSN号 | 1010-4283 |
| DOI | 10.1007/s13277-014-1689-3 |
| 文献子类 | Article |
| 英文摘要 | Cytochrome P450 (CYP) 2C19 is expressed in vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which play a crucial role in either the detoxification or inactivation of potential carcinogens, or the bioactivation of some environmental procarcinogens to reactive DNA-binding metabolites. And smoking is a major risk factor for lung cancer. The purpose of this study is to explore the relationship between the interaction of CYP2C19*3 polymorphism and smoking and lung cancer in a Chinese population. In a Chinese case-control study of lung cancer patients (n = 420) and healthy controls (n = 420), we investigated the roles of CYP2C19*3 polymorphism in lung cancer risk using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. We found that the frequency of CYP2C19 (*)3 (AG + AA) genotype was significantly higher in lung cancer patients than that in control subjects (14.28 % versus 4.76 %; P < 0.001). Multivariable logistic regression analysis showed that after adjustment of other risk factors, the A allele of CYP2C19*3 remains significantly associated with lung cancer. We also found that there was a significant interaction between CYP2C19 (*)3 and smoking in increasing the risk for lung cancer (OR 5.121, 95 % confidence interval [CI] 4.321-10.124; P = 0.001). The interaction between CYP2C19 (*)3 polymorphism and smoking plays an important role in the mechanism of lung cancer in Chinese population. |
| WOS关键词 | CYP2C19 GENOTYPE ; ASSOCIATION ; IMPACT |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000337094900030 |
| 出版者 | SAGE PUBLICATIONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277051]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Xing-Hua |
| 作者单位 | 1.Eighth Peoples Hosp Shanghai, Dept Oncol, Shanghai 200233, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 3.Pulm Hosp Shanghai, Dept Respirat, Shanghai 200433, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yan, Fei,Xu, Jin-Fu,Liu, Xiao-fang,et al. Interaction between smoking and CYP2C19*3 polymorphism increased risk of lung cancer in a Chinese population[J]. TUMOR BIOLOGY,2014,35(6):5295-5298. |
| APA | Yan, Fei,Xu, Jin-Fu,Liu, Xiao-fang,&Li, Xing-Hua.(2014).Interaction between smoking and CYP2C19*3 polymorphism increased risk of lung cancer in a Chinese population.TUMOR BIOLOGY,35(6),5295-5298. |
| MLA | Yan, Fei,et al."Interaction between smoking and CYP2C19*3 polymorphism increased risk of lung cancer in a Chinese population".TUMOR BIOLOGY 35.6(2014):5295-5298. |
入库方式： OAI收割
来源：上海药物研究所
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