Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion
文献类型：期刊论文
| 作者 | Jian, Hong2; Liu, Bin1; Zhang, Jie3 |
| 刊名 | TUMOR BIOLOGY
 |
| 出版日期 | 2014-05 |
| 卷号 | 35期号:5页码:4949-4955 |
| 关键词 | Sema domain of semaphorin 4B Hypoxia-inducible factor 1 Invasion Lung cancer |
| ISSN号 | 1010-4283 |
| DOI | 10.1007/s13277-014-1651-4 |
| 文献子类 | Article |
| 英文摘要 | Sema domain of semaphorin 4B (SEMA4B), which is an interacting protein of LNM35, plays an important role in lung cancer invasion. However, the regulation mechanism of this protein is completely unknown. Here, we report that hypoxia and hypoxia mimic reagent could downregulate the expression of SEMA4B in human non-small cell lung cancer (NSCLC) lines. We provide evidences that SEMA4B is a direct target of hypoxia-inducible factor 1 (HIF-1). Silencing the expression of HIF-1 alpha in cancer cells by RNA interference abolished hypoxia-repressed SEMA4B expression. Using luciferase reporter assay, we showed that HIF-1 alpha recognized a hypoxia-responsive element (HRE) of SEMA4B gene, which is required for HIF-1-repressed SEMA4B expression. Moreover, ectopic expression of SEMA4B abolished invasion of hypoxia-induced NSCLC cells. Taken together, these data would shed novel insights on the mechanisms for invasion of hypoxia-induced NSCLC cells. |
| WOS关键词 | E-CADHERIN ; HIF ; TRANSCRIPTION ; HYDROXYLATION ; ANGIOGENESIS ; METASTASIS ; OXYGEN ; SNAIL |
| 资助项目 | WU JIE PING Medical foundation[00000000] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000335759800118 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277096]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jie |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai Lung Tumor Clin Med Ctr, Shanghai 200030, Peoples R China; 3.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Pathol, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jian, Hong,Liu, Bin,Zhang, Jie. Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion[J]. TUMOR BIOLOGY,2014,35(5):4949-4955. |
| APA | Jian, Hong,Liu, Bin,&Zhang, Jie.(2014).Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion.TUMOR BIOLOGY,35(5),4949-4955. |
| MLA | Jian, Hong,et al."Hypoxia and hypoxia-inducible factor 1 repress SEMA4B expression to promote non-small cell lung cancer invasion".TUMOR BIOLOGY 35.5(2014):4949-4955. |
入库方式： OAI收割
来源：上海药物研究所
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