Downregulated Expression of the Cyclase-associated Protein 1 (CAP1) Reduces Migration in Esophageal Squamous Cell Carcinoma
文献类型：期刊论文
| 作者 | Li, Mei2; Yang, Xiaojing2; Shi, Hui1; Ren, Hanru1; Chen, Xueyu4; Zhang, Shu1; Zhu, Junya3; Zhang, Jianguo1 |
| 刊名 | JAPANESE JOURNAL OF CLINICAL ONCOLOGY
 |
| 出版日期 | 2013-09 |
| 卷号 | 43期号:9页码:856-864 |
| ISSN号 | 0368-2811 |
| 关键词 | carcinoma squamous cell cell migration |
| DOI | 10.1093/jjco/hyt093 |
| 文献子类 | Article |
| 英文摘要 | Overexpression of cyclase-associated proteins has been associated with poor prognosis in several human cancers. Cyclase-associated protein 1 is a member of the cyclase-associated proteins which contributes to tumor progression. The aim of the present study was to examine the expression of cyclase-associated protein 1 and to elucidate its clinicopathologic signicance in a larger series of esophageal squamous cell carcinoma. Immunohistochemical and western blot analyses were performed in esophageal squamous cell carcinoma tissues. Survival analyses were performed by using the KaplanMeier method. The role of cyclase-associated protein 1 in migration was studied in esophageal squamous cell carcinoma cell lines of TE1 through knocking down cyclase-associated protein 1 with siRNA and overexpression of cyclase-associated protein 1. The regulation of cyclase-associated protein 1 on migration was determined by transwell and wound-healing assays. Immunohistochemical analysis showed that cyclase-associated protein 1 expression was negatively associated with E-cadherin and signicantly associated with lymph node metastases. Survival analysis revealed that cyclase-associated protein 1 overexpression was signicantly associated with overall survival (P 0.011). Knock down of cyclase-associated protein 1 in TE1 cells resulted in decreased vimentin and F-actin levels and the capability for migration. In addition, overexpression of cyclase-associated protein 1 promoted the migration of TE1 cells. These ndings suggest that cyclase-associated protein 1 is involved in the metastasis of esophageal squamous cell carcinoma, and that elevated levels of cyclase-associated protein 1 expression may indicate a poor prognosis for patients with esophageal squamous cell carcinoma. |
| WOS关键词 | EPITHELIAL-MESENCHYMAL TRANSITIONS ; ADENYLATE-CYCLASE ; CANCER ; ACTIN ; OVEREXPRESSION ; YEAST ; PROGRESSION ; INVASION ; POLARITY ; COMPLEX |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | OXFORD UNIV PRESS |
| WOS记录号 | WOS:000323952100002 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277482]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jianguo |
| 作者单位 | 1.Nantong Univ, Affiliated Hosp, Dept Pathol, Nantong 226001, Jiangsu, Peoples R China; 2.Nantong Univ, Affiliated Hosp, Dept Med Oncol, Nantong 226001, Jiangsu, Peoples R China; 3.Nantong Univ, Coll Med, Dept Immunol, Nantong 226001, Jiangsu, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mei,Yang, Xiaojing,Shi, Hui,et al. Downregulated Expression of the Cyclase-associated Protein 1 (CAP1) Reduces Migration in Esophageal Squamous Cell Carcinoma[J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY,2013,43(9):856-864. |
| APA | Li, Mei.,Yang, Xiaojing.,Shi, Hui.,Ren, Hanru.,Chen, Xueyu.,...&Zhang, Jianguo.(2013).Downregulated Expression of the Cyclase-associated Protein 1 (CAP1) Reduces Migration in Esophageal Squamous Cell Carcinoma.JAPANESE JOURNAL OF CLINICAL ONCOLOGY,43(9),856-864. |
| MLA | Li, Mei,et al."Downregulated Expression of the Cyclase-associated Protein 1 (CAP1) Reduces Migration in Esophageal Squamous Cell Carcinoma".JAPANESE JOURNAL OF CLINICAL ONCOLOGY 43.9(2013):856-864. |
入库方式： OAI收割
来源：上海药物研究所
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