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MicroRNA-16 Inhibits Bladder Cancer Proliferation by Targeting Cyclin D1

文献类型：期刊论文

作者Jiang, Qi-Quan1; Liu, Bin2; Yuan, Tao1
刊名ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
出版日期2013
卷号14期号:7页码:4127-4130
关键词MicroRNA-16 Cyclin D1 bladdercancer cell proliferation
ISSN号1513-7368
DOI10.7314/APJCP.2013.14.7.4127
文献子类Article
英文摘要MicroRNA-16 (miR-16) has been demonstrated to regulate proliferation and apoptosis in many types of cancers, but its biological function in bladder cancer remains unknown. Here, we found expression of miR-16 to be downregulated in bladder cancer in comparison with the adjacent normal tissues. Enforced expression of miR-16 was able to inhibit cell proliferation in TCHu-1 cells, in line with results for miR-16 antisense oligonucleotides (antisense miR-16). At the molecular level, our results further revealed that cyclin D1 expression was negatively regulated by miR-16. Therefore, the data reported here demonstrate that miR-16 is an important regulator in bladder cancer, which will contribute to better understanding of important mis-regulated miRNAs.
WOS关键词SIGNALING PATHWAY ; EXPRESSION ; CARCINOMA ; DELIVERY ; THERAPY ; MIR-15A ; GROWTH ; CELLS
WOS研究方向Oncology
语种英语
WOS记录号WOS:000328269400021
出版者ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
源URL[http://119.78.100.183/handle/2S10ELR8/277774]  
专题中国科学院上海药物研究所
通讯作者Yuan, Tao
作者单位1.Tongji Univ, Affiliated Tongji Hosp, Dept Urol, Shanghai 200092, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Qi-Quan,Liu, Bin,Yuan, Tao. MicroRNA-16 Inhibits Bladder Cancer Proliferation by Targeting Cyclin D1[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2013,14(7):4127-4130.
APA Jiang, Qi-Quan,Liu, Bin,&Yuan, Tao.(2013).MicroRNA-16 Inhibits Bladder Cancer Proliferation by Targeting Cyclin D1.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,14(7),4127-4130.
MLA Jiang, Qi-Quan,et al."MicroRNA-16 Inhibits Bladder Cancer Proliferation by Targeting Cyclin D1".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 14.7(2013):4127-4130.

入库方式： OAI收割

来源：上海药物研究所

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