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SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells

文献类型：期刊论文

作者Tan, Ming-Yue1; Mu, Xing-Yu1; Liu, Bin2; Wang, Yong1; Bao, Er-Dun1; Qiu, Jian-Xin1; Fan, Yu1
刊名CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
出版日期2013
卷号32期号:3页码:542-548
关键词SENP2 Metastasis MMP13 Bladder cancer cells
ISSN号1015-8987
DOI10.1159/000354458
文献子类Article
英文摘要Background: SUMO-specific protease 2 (SENP2) is a de-SUMOylation protease family member which has an indispensable role in the regulation of NF-B-K transcriptional activation and Wnt signaling. However, whether SENP2 plays a role in tumor metastasis is completely unknown. Methods: Real-time PCR and Western blot was used to detect the expression of SENP2 in human bladder cancer samples and cell lines. Small interfering RNA (siRNA) was used to silencing the expression of SENP2. Matrigel-coated invasion chambers were used to detect the invasion ability of SENP2 in bladder cancer cells. Results: SENP2 was downregulated in bladder cancer samples. SENP2 inhibited bladder cancer cells migration and invasion in vitro. Transcriptional analysis of several genes associated with tumor metastasis and invasion demonstrated that SENP2 selectively down-regulated MMP13 in bladder cancer cells. Further analysis indicated that silencing of MMP13 rescued the invasive phenotype in SENP2 expressing T24 cells. Conclusion: SENP2 functions as a tumor metastasis suppressor in bladder cancer. The effects of SENP2 on bladder cancer invasion are partially mediated by inhibiting the expression of MMP13. Copyright (C) 2013 S. Karger AG, Basel
WOS关键词EMERGING MECHANISMS ; METASTASIS ; SUMOYLATION ; PROGRESSION ; ROLES
WOS研究方向Cell Biology ; Physiology
语种英语
WOS记录号WOS:000325415900005
出版者KARGER
源URL[http://119.78.100.183/handle/2S10ELR8/277786]  
专题中国科学院上海药物研究所
通讯作者Fan, Yu
作者单位1.Shanghai Jiao Tong Univ, Dept Urol, Affiliated Peoples Hosp 1, Shanghai 200080, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714		 Tan, Ming-Yue,Mu, Xing-Yu,Liu, Bin,et al. SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2013,32(3):542-548.
APA Tan, Ming-Yue.,Mu, Xing-Yu.,Liu, Bin.,Wang, Yong.,Bao, Er-Dun.,...&Fan, Yu.(2013).SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,32(3),542-548.
MLA Tan, Ming-Yue,et al."SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 32.3(2013):542-548.

入库方式： OAI收割

来源：上海药物研究所

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