Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera. Cytotoxic activity of the metabolites against human prostate cancer cells
文献类型：期刊论文
| 作者 | Chen, Guangtong1; Yang, Min2; Nong, Shaojun1; Yang, Xue1; Ling, Yong1; Wang, Donggeng1; Wang, Xinyang1; Zhang, Wei1 |
| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2013-01 |
| 卷号 | 84页码:6-10 |
| 关键词 | Microbial transformation Absidia corymbifera AS 3.3387 20(S)-Protopanaxadiol Dehydrogenation Hydroxylation Cytotoxic activity |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2012.09.018 |
| 文献子类 | Article |
| 英文摘要 | Biotransformation of 20(S)-protopanaxadiol (1) by the fungus Absidia corymbifera AS 3.3387 yielded five metabolites (2-6). On the basis of spectroscopic data analyses, the metabolites were identified as 26-hydroxyl-20(S)-protopanaxadiol (2), 23, 24-en-25-hydroxyl-20(S)-protopanaxadiol (3), 25-hydroxyl-20(S)-protopanaxadiol (4), 7 beta-hydroxyl-20(S)-protopanaxatriol (5), and 7-oxo-20(S)-protopanaxatriol (6), respectively. Among them, 5 and 6 are new compounds. These results indicated that A. corymbifera AS 3.3387 could catalyze the side-chain oxidation-reduction, 7 beta hydroxylation, and the specific C-7 dehydrogenation of derivatives of 20(S)-protopanaxadiol. The metabolites 2, 5, and 6 showed the more potent inhibitory effects against DU-145 and PC-3 cell lines than the substrate. (c) 2012 Elsevier B.V. All rights reserved. |
| WOS关键词 | BIOCHEMICAL RECURRENCE ; RADICAL PROSTATECTOMY ; PROTOPANAXATRIOL ; SAPONINS ; RISK |
| 资助项目 | Natural Science Foundation of the Jiangsu Higher Education Institutions of China[10KJB350003] ; National Natural Science Foundation of China[81102327] ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000316531400002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277799]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Wei |
| 作者单位 | 1.Nantong Univ, Sch Med, Nantong 226001, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Guangtong,Yang, Min,Nong, Shaojun,et al. Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera. Cytotoxic activity of the metabolites against human prostate cancer cells[J]. FITOTERAPIA,2013,84:6-10. |
| APA | Chen, Guangtong.,Yang, Min.,Nong, Shaojun.,Yang, Xue.,Ling, Yong.,...&Zhang, Wei.(2013).Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera. Cytotoxic activity of the metabolites against human prostate cancer cells.FITOTERAPIA,84,6-10. |
| MLA | Chen, Guangtong,et al."Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera. Cytotoxic activity of the metabolites against human prostate cancer cells".FITOTERAPIA 84(2013):6-10. |
入库方式： OAI收割
来源：上海药物研究所
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