Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity
文献类型：期刊论文
| 作者 | Liu, Han-Wei2; Yu, Xiu-Zhu2; Padula, Daniele3; Pescitelli, Gennaro3; Lin, Zhi-Wei4; Wang, Fei4; Ding, Kai1; Lei, Ming2; Gao, Jin-Ming2 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2013-01 |
| 卷号 | 59页码:265-273 |
| ISSN号 | 0223-5234 |
| 关键词 | Natural products Structure elucidation Circular dichroism Estrogenic activity Antitumor agents Schisandra sphenathera Rehd. et Wils |
| DOI | 10.1016/j.ejmech.2012.11.003 |
| 文献子类 | Article |
| 英文摘要 | A new dibenzocyclooctene-type lignan, named schisandrin A1 (1), together with nine known lignans (2-10), was isolated from the stems of Schisandra sphenathera. The structure of schisandrin A1, which contains a spirocyclic epoxy unit, was established by means of spectroscopic methods. The absolute configurations of schisandrin A1 (1) and schisantherin A (2) were determined by electronic circular dichroism (CD) and TDDFT calculations, with 2 further confirmed by X-ray crystallographic data. Ten new schisantherin A derivatives (11-20) and 6,7-secoschisantherol A (2b) were synthesized. In addition, natural lignans and semisynthetic schisantherin A derivatives showed the antiproliferative activity on four human cancer cell lines and Id1 (an inhibitor of DNA binding protein) and estrogenic potency. Compounds 5, 7, and 8 exhibited very potent estrogenic activity. (C) 2012 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | SCHIZANDRA-CHINENSIS BAILL ; DIBENZOCYCLOOCTADIENE LIGNANS ; CIRCULAR-DICHROISM ; SOLID-STATE ; CHIROPTICAL PROPERTIES ; CANCER-CELLS ; CD SPECTRA ; GOMISIN-F ; SPHENANTHERA ; CONSTITUENTS |
| 资助项目 | National Forestry Public Welfare Industry Research Project[201204603] ; China Postdoctoral Science Foundation[20110491694] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:000315554100030 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277805]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gao, Jin-Ming |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China 2.Northwest A&F Univ, Coll Sci, Shaanxi Engn Ctr Bioresource Chem & Sustainable U, Yangling 712100, Shaanxi, Peoples R China; 3.Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy; 4.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Han-Wei,Yu, Xiu-Zhu,Padula, Daniele,et al. Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,59:265-273. |
| APA | Liu, Han-Wei.,Yu, Xiu-Zhu.,Padula, Daniele.,Pescitelli, Gennaro.,Lin, Zhi-Wei.,...&Gao, Jin-Ming.(2013).Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,59,265-273. |
| MLA | Liu, Han-Wei,et al."Lignans from Schisandra sphenathera Rehd. et Wils. and semisynthetic schisantherin A analogues: Absolute configuration, and their estrogenic and anti-proliferative activity".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 59(2013):265-273. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。