Virus-host interactomes - antiviral drug discovery
文献类型：期刊论文
| 作者 | Ma-Lauer, Yue2; Lei, Jian1,3; Hilgenfeld, Rolf1,3,4; von Brunn, Albrecht2 |
| 刊名 | CURRENT OPINION IN VIROLOGY
 |
| 出版日期 | 2012-10 |
| 卷号 | 2期号:5页码:614-621 |
| ISSN号 | 1879-6257 |
| DOI | 10.1016/j.coviro.2012.09.003 |
| 文献子类 | Article |
| 英文摘要 | One of the key questions in virology is how viruses, encoding relatively few genes, gain temporary or constant control over their hosts. To understand pathogenicity of a virus it is important to gain knowledge on the function of the individual viral proteins in the host cell, on their interactions with viral and cellular proteins and on the consequences of these interactions on cellular signaling pathways. A combination of transcriptomics, proteomics, high-throughput technologies and the bioinformatical analysis of the respective data help to elucidate specific cellular antiviral drug target candidates. In addition, viral and human interactome analyses indicate that different viruses target common, central human proteins for entering cellular signaling pathways and machineries which might constitute powerful broad-spectrum antiviral targets. |
| WOS关键词 | PROTEIN-PROTEIN INTERACTIONS ; HUMAN CYCLOPHILIN-A ; CYCLOSPORINE-A ; COMPLEMENTATION ASSAY ; CELLULAR-PROTEINS ; IN-VITRO ; REPLICATION ; CELLS ; HIV-1 ; INHIBITORS |
| 资助项目 | 'Bundesministerium fur Bildung und Forschung' of the German Federal Government (Zoonosis Network, Consortium on ecology and pathogenesisis of SARS)[01KI1005A] ; 'Bundesministerium fur Bildung und Forschung' of the German Federal Government (Zoonosis Network, Consortium on ecology and pathogenesisis of SARS)[F] ; DEG through its Cluster of Excellence 'Inflammation at Interfaces'[EXC 306] ; Fonds der Chemischen Industrie[00000000] ; Chinese Academy of Sciences through a Visiting Professorship for Senior International Scientists[2010T1S6] ; Schleswig-Holstein Innovation Fund[00000000] ; European Commission through its SILVER project[HEALTH-F3-2010-260644] |
| WOS研究方向 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000312228400015 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277915]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | von Brunn, Albrecht |
| 作者单位 | 1.Univ Lubeck, Gerrnan Ctr Infect Res DZIF, D-23538 Lubeck, Germany; 2.Univ Munich, Max von Pettenkofer Inst, D-80336 Munich, Germany; 3.Univ Lubeck, Ctr Struct & Cell Biol Med, Inst Biochem, D-23538 Lubeck, Germany; 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma-Lauer, Yue,Lei, Jian,Hilgenfeld, Rolf,et al. Virus-host interactomes - antiviral drug discovery[J]. CURRENT OPINION IN VIROLOGY,2012,2(5):614-621. |
| APA | Ma-Lauer, Yue,Lei, Jian,Hilgenfeld, Rolf,&von Brunn, Albrecht.(2012).Virus-host interactomes - antiviral drug discovery.CURRENT OPINION IN VIROLOGY,2(5),614-621. |
| MLA | Ma-Lauer, Yue,et al."Virus-host interactomes - antiviral drug discovery".CURRENT OPINION IN VIROLOGY 2.5(2012):614-621. |
入库方式： OAI收割
来源：上海药物研究所
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