中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells

文献类型:期刊论文

作者Mei, De-Sheng1,2; He, Bao-Kun3; Chen, Lei2; Yao, Zhu-Jun2
刊名TETRAHEDRON LETTERS
出版日期2012-07-04
卷号53期号:27页码:3463-3466
关键词Methylmercury Anti-MeHg+ agents Fluorescent sensing Pyrrolcoumarin Living cells
ISSN号0040-4039
DOI10.1016/j.tetlet.2012.04.113
文献子类Article
英文摘要Methylmercury (MeHg+) is one of the most toxic mercury species targeting human nervous systems, and deficiency of a convenient and precise appraisal model for anti-MeHg+ treatment greatly slows down the step of developing clinically useful anti-MeHg+ agents. A simple visualization model has been demonstrated in this work for selective sensing of both MeHg+ and anti-MeHg+ agents in two continuous stages of one experiment in living cells, using a newly developed fluorescent pyrrolcoumarin probe. The developed sensing protocol shows great potential in the future applications of screening and evaluation of anti-MeHg+ agents. (C) 2012 Elsevier Ltd. All rights reserved.
WOS关键词METHYLMERCURY-INDUCED NEUROTOXICITY ; OXIDATIVE STRESS ; MERCURY ; SENSOR ; MECHANISMS ; EXPOSURE ; TISSUE ; ACID ; DMPS ; ION
资助项目NSFC[21032002] ; NSFC[90713044] ; 973 Program[2010CB833200]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000306152500014
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/278021]  
专题中国科学院上海药物研究所
通讯作者Yao, Zhu-Jun
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Med Chem Lab, Shanghai 201203, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China;
3.Beijing Inst Radiat Med, Dept Pharmacol & Toxicol, Beijing 100850, Peoples R China
推荐引用方式
GB/T 7714
Mei, De-Sheng,He, Bao-Kun,Chen, Lei,et al. A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells[J]. TETRAHEDRON LETTERS,2012,53(27):3463-3466.
APA Mei, De-Sheng,He, Bao-Kun,Chen, Lei,&Yao, Zhu-Jun.(2012).A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells.TETRAHEDRON LETTERS,53(27),3463-3466.
MLA Mei, De-Sheng,et al."A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells".TETRAHEDRON LETTERS 53.27(2012):3463-3466.

入库方式: OAI收割

来源:上海药物研究所

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