A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells
文献类型：期刊论文
| 作者 | Mei, De-Sheng1,2; He, Bao-Kun3; Chen, Lei2; Yao, Zhu-Jun2 |
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2012-07-04 |
| 卷号 | 53期号:27页码:3463-3466 |
| 关键词 | Methylmercury Anti-MeHg+ agents Fluorescent sensing Pyrrolcoumarin Living cells |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2012.04.113 |
| 文献子类 | Article |
| 英文摘要 | Methylmercury (MeHg+) is one of the most toxic mercury species targeting human nervous systems, and deficiency of a convenient and precise appraisal model for anti-MeHg+ treatment greatly slows down the step of developing clinically useful anti-MeHg+ agents. A simple visualization model has been demonstrated in this work for selective sensing of both MeHg+ and anti-MeHg+ agents in two continuous stages of one experiment in living cells, using a newly developed fluorescent pyrrolcoumarin probe. The developed sensing protocol shows great potential in the future applications of screening and evaluation of anti-MeHg+ agents. (C) 2012 Elsevier Ltd. All rights reserved. |
| WOS关键词 | METHYLMERCURY-INDUCED NEUROTOXICITY ; OXIDATIVE STRESS ; MERCURY ; SENSOR ; MECHANISMS ; EXPOSURE ; TISSUE ; ACID ; DMPS ; ION |
| 资助项目 | NSFC[21032002] ; NSFC[90713044] ; 973 Program[2010CB833200] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000306152500014 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278021]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yao, Zhu-Jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Med Chem Lab, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China; 3.Beijing Inst Radiat Med, Dept Pharmacol & Toxicol, Beijing 100850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mei, De-Sheng,He, Bao-Kun,Chen, Lei,et al. A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells[J]. TETRAHEDRON LETTERS,2012,53(27):3463-3466. |
| APA | Mei, De-Sheng,He, Bao-Kun,Chen, Lei,&Yao, Zhu-Jun.(2012).A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells.TETRAHEDRON LETTERS,53(27),3463-3466. |
| MLA | Mei, De-Sheng,et al."A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells".TETRAHEDRON LETTERS 53.27(2012):3463-3466. |
入库方式： OAI收割
来源：上海药物研究所
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