Protective effects of the ethanolic extract of Melia toosendan fruit against colon cancer
文献类型：期刊论文
| 作者 | Tang, Xue-Lian1,2; Yang, Xin-Ying2,7; Kim, Youn-Chul5; Kim, Sung-Yeon5; Kang, Baek-Dong3; Choi, Du-Young4; Kim, Ok-Jin6; Park, Won-Cheol3; Park, Hyun2 |
| 刊名 | INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
 |
| 出版日期 | 2012-06 |
| 卷号 | 49期号:3页码:173-181 |
| 关键词 | Melia toosendan fruit Colon cancer Apoptosis |
| ISSN号 | 0301-1208 |
| 文献子类 | Article |
| 英文摘要 | Colorectal cancer is one of the leading causes of death in the world. Plant-derived products have proven to be valuable sources for discovery and development of unique anticancer drugs. In this study, the inhibitory effects of ethanolic extract of Melia toosendan fruit (EMTF), a traditional medicine in the Chinese Pharmacopeia were evaluated in vitro and in vivo against colon cancer. Human colon cancer cells SW480 and murine colorectal adenocarcinoma cells CT26 were used to investigate cell proliferation. The results showed that EMTF inhibited cell proliferation of SW480 and CT26 by promoting apoptosis as indicated by nuclear chromatin condensation and DNA fragmentation. Through increasing mitochondrial membrane permeability and cytochrome c release from mitochondria, EMTF induced caspase-9 activity which further activated caspase-3 and poly(ADP-ribose) polymerase cleavage, leading the tumor cells to apoptosis. The in vivo results confirmed reduction of tumor volume and apoptotic effects and the side effects were not induced by EMTF. Therefore, EMTF may be an effective chemotherapeutic agent for colon cancer treatment. |
| WOS关键词 | CHINESE TRADITIONAL MEDICINE ; PLANT ANTITUMOR AGENTS ; DNA FRAGMENTATION ; COLORECTAL-CANCER ; GROWTH-INHIBITION ; CELL-DEATH ; APOPTOSIS ; MITOCHONDRIA ; CASPASES |
| 资助项目 | National Research Foundation of Korea (NRF)[00000000] ; Ministry of Education, Science and Technology[2011-0020967] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000306146400004 |
| 出版者 | NATL INST SCIENCE COMMUNICATION-NISCAIR |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278046]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Park, Hyun |
| 作者单位 | 1.S China Agr Univ, Coll Anim Sci, Dept Aquaculture, Guangzhou 510642, Guangdong, Peoples R China; 2.Wonkwang Univ, Dept Infect Biol, Zoonosis Res Ctr, Iksan 570749, Jeonbuk, South Korea; 3.Wonkwang Univ, Dept Surg, Iksan 570749, Jeonbuk, South Korea; 4.Wonkwang Univ, Sch Med, Dept Pediat, Iksan 570749, Jeonbuk, South Korea; 5.Wonkwang Univ, Coll Pharm, Iksan 570749, Jeonbuk, South Korea; 6.Wonkwang Univ, Ctr Anim Resources, Iksan 570749, Jeonbuk, South Korea; 7.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Xue-Lian,Yang, Xin-Ying,Kim, Youn-Chul,et al. Protective effects of the ethanolic extract of Melia toosendan fruit against colon cancer[J]. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS,2012,49(3):173-181. |
| APA | Tang, Xue-Lian.,Yang, Xin-Ying.,Kim, Youn-Chul.,Kim, Sung-Yeon.,Kang, Baek-Dong.,...&Park, Hyun.(2012).Protective effects of the ethanolic extract of Melia toosendan fruit against colon cancer.INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS,49(3),173-181. |
| MLA | Tang, Xue-Lian,et al."Protective effects of the ethanolic extract of Melia toosendan fruit against colon cancer".INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 49.3(2012):173-181. |
入库方式： OAI收割
来源：上海药物研究所
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