New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.
文献类型：期刊论文
| 作者 | Zhang, Hua; Conte, Melissa M.; Khalil, Zeinab; Huang, Xiao-Cong; Capon, Robert J. |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2012 |
| 卷号 | 2期号:10页码:4209-4214 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c2ra20322g |
| 文献子类 | Article |
| 英文摘要 | Chemical analysis of a southern Australian marine sponge, an Ianthella sp., yielded dictyodendrins F-J (1-5) as new examples of a rare class of marine alkaloid. Structures were assigned on the basis of detailed spectroscopic analysis, while biosynthetic considerations suggested a relationship between the dictyodendrins and co-metabolites belonging to the lamellarin and ianthellidone structure classes. The dictyodendrins 1 and 3-5 exhibited significant BACE inhibitory activity (IC50 1-2 mu M), with the differential cytotoxicity displayed by 1-4 towards two human colon cancer cell lines (IC50 2-16 mu M) marking them as both cytotoxins and probable substrates for the multi-drug resistance efflux pump P-glycoprotein. The dictyodendrins 1-5 did not inhibit growth of Gram -ve bacteria or fungi, but 1, 3, and 4 were selective Gram +ve antibacterials (IC50 1-3 mu M). Dictyodendrin J (5), with its unique seco-carbon skeleton and unusual 1,2-diketone functionality, exhibited a promising non-cytotoxic biological activity profile, inclusive of significant BACE inhibitory activity (IC50 2 mu M), supportive of further investigation. |
| WOS关键词 | ALZHEIMERS-DISEASE ; A-E |
| 资助项目 | University of Queensland[00000000] ; Institute for Molecular Bioscience[00000000] ; Australian Research Council (ARC)[LP0775547] ; Noscira (Madrid, Spain)[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000304327300029 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278258]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Hua |
| 作者单位 | Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, St Lucia, Qld 4072, Australia |
| 推荐引用方式 GB/T 7714 | Zhang, Hua,Conte, Melissa M.,Khalil, Zeinab,et al. New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.[J]. RSC ADVANCES,2012,2(10):4209-4214. |
| APA | Zhang, Hua,Conte, Melissa M.,Khalil, Zeinab,Huang, Xiao-Cong,&Capon, Robert J..(2012).New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp..RSC ADVANCES,2(10),4209-4214. |
| MLA | Zhang, Hua,et al."New dictyodendrins as BACE inhibitors from a southern Australian marine sponge, Ianthella sp.".RSC ADVANCES 2.10(2012):4209-4214. |
入库方式： OAI收割
来源：上海药物研究所
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