The involvement of RGS9 in L-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model
文献类型：期刊论文
| 作者 | Yin, Lin-Lin2,4; Geng, Xing-Chao1,3; Zhu, Xing-Zu4 |
| 刊名 | BRAIN RESEARCH BULLETIN
 |
| 出版日期 | 2011-11-25 |
| 卷号 | 86期号:5-6页码:367-372 |
| 关键词 | Regulators of G-proteins signaling proteins 6-Hydroxydopamine-lesioned rat L-3,4-Dihydroxyphenylalanine Dyskinesia Parkinson's disease |
| ISSN号 | 0361-9230 |
| DOI | 10.1016/j.brainresbull.2011.09.016 |
| 文献子类 | Article |
| 英文摘要 | Chronic dopamine (DA) replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) in Parkinson's disease (PD) often leads to abnormal involuntary movements (AIMs) known as L-DOPA-induced dyskinesia (LID), mediated by DA receptors. However, mechanisms underlying LID occurrence are still unclear. Regulator of G-protein signaling RGS9, a member of the RGS family of GTPase accelerating proteins, is expressed specifically in the striatum, has been reported participated in LID. L-DOPA-induced AIMs can be modeled in rats with 6-hydroxydopamine (6-OHDA) lesions by chronic injection of L-DOPA. Herein, we compared the rotational responses and AIMs in 6-OHDA lesioned rats with L-DOPA/benserazide (10/2.5 mg/kg, once per day, i.p.) administration for 14 days whereas control animals received injections of saline. Furthermore, whether sub-chronic L-DOPA treatment impact RGS9 mRNA or protein expression in 6-OHDA lesion rats were also evaluated. As results shown, rotational behavior was not increased significantly, while an obvious AIMs were observed in rats with L-DOPA/benserazide (10/2.5 mg/kg, i.p.) administration sub-chronically. In addition, expressions of RGS9 protein or mRNA analyzed by Western blot or real-time PCR with striatal extracts increased significantly after L-DOPA/benserazide. These data demonstrate that RGS9 expression can be modulated by sub-chronic L-DOPA/benserazide administration and increased RGS9 expression in striatum may be one of the reasons for the side effects such as dyskinesia induced by L-DOPA therapy. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved. |
| WOS关键词 | MEDIAL FOREBRAIN-BUNDLE ; DOPA-INDUCED DYSKINESIA ; PROTEIN SIGNALING RGS ; TIME QUANTITATIVE PCR ; PARKINSONS-DISEASE ; ROTATIONAL BEHAVIOR ; SUBSTANTIA-NIGRA ; MESSENGER-RNA ; RECEPTORS ; 6-HYDROXYDOPAMINE |
| 资助项目 | National Natural Science Foundation of China[81001656] ; Beijing Municipal Science Technology[2010B070] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000298711300011 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278331]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yin, Lin-Lin |
| 作者单位 | 1.Natl Inst Food & Drug Control, Beijing 100050, Peoples R China; 2.Capital Med Univ, Beijing Geriatr Med Res Ctr, Key Lab Neurodegenerat Dis, Dept Pharmacol,Xuanwu Hosp,Minist Educ, Beijing 100053, Peoples R China; 3.Fourth Mil Med Univ, Sch Pharm, Ctr Biotechnol, Xian 710032, Peoples R China; 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol 2, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yin, Lin-Lin,Geng, Xing-Chao,Zhu, Xing-Zu. The involvement of RGS9 in L-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model[J]. BRAIN RESEARCH BULLETIN,2011,86(5-6):367-372. |
| APA | Yin, Lin-Lin,Geng, Xing-Chao,&Zhu, Xing-Zu.(2011).The involvement of RGS9 in L-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model.BRAIN RESEARCH BULLETIN,86(5-6),367-372. |
| MLA | Yin, Lin-Lin,et al."The involvement of RGS9 in L-3,4-dihydroxyphenylalanine-induced dyskinesias in unilateral 6-OHDA lesion rat model".BRAIN RESEARCH BULLETIN 86.5-6(2011):367-372. |
入库方式： OAI收割
来源：上海药物研究所
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