Highly Stereoselective Trichloromethylation of N-(tert-Butylsulfinyl)aldimines: Facile Synthesis of Chiral alpha-Trichloromethylamines
文献类型：期刊论文
| 作者 | Li, Ya1; Cao, Yunlv1; Gu, Jiaying1; Wang, Wei1; Wang, Han1; Zheng, Tao1; Sun, Zhihua1,2 |
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2011-02 |
| 期号 | 4页码:676-679 |
| 关键词 | Sulfur Amines Nucleophilic addition Diastereoselectivity Trichloromethylation |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201001495 |
| 文献子类 | Article |
| 英文摘要 | The first highly stereoselective and facile synthesis of alpha-trichloromethylamines is described by using a nucleophilic trichloromethylation strategy. With tetrabutylammonium triphenyldifluorosilicate (TBAT) as the mediator, the tri-chloromethyl anion (CCl(3)(-)) from TMSCCl(3) can be transferred to N-(tert-butylsulfinyl)aldimines in excellent yields and with high diastereoselectivity (greater than or similar to 99:1 dr). |
| WOS关键词 | TRIHALOGENOACETIC ACIDS ; ASYMMETRIC-SYNTHESIS ; RADICAL CYCLIZATION ; BETA-SULTAMS ; DERIVATIVES ; AMINES ; REACTIVITY ; ENAMINES ; IMINES ; TRIFLUOROMETHYLATION |
| 资助项目 | Shanghai University of Engineering Science[00000000] ; State Laboratory of Drug Research (CAS)[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000287163000004 |
| 出版者 | WILEY-BLACKWELL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278614]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Ya |
| 作者单位 | 1.Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Lab Drug Res, Shanghai 201620, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ya,Cao, Yunlv,Gu, Jiaying,et al. Highly Stereoselective Trichloromethylation of N-(tert-Butylsulfinyl)aldimines: Facile Synthesis of Chiral alpha-Trichloromethylamines[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2011(4):676-679. |
| APA | Li, Ya.,Cao, Yunlv.,Gu, Jiaying.,Wang, Wei.,Wang, Han.,...&Sun, Zhihua.(2011).Highly Stereoselective Trichloromethylation of N-(tert-Butylsulfinyl)aldimines: Facile Synthesis of Chiral alpha-Trichloromethylamines.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(4),676-679. |
| MLA | Li, Ya,et al."Highly Stereoselective Trichloromethylation of N-(tert-Butylsulfinyl)aldimines: Facile Synthesis of Chiral alpha-Trichloromethylamines".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .4(2011):676-679. |
入库方式： OAI收割
来源：上海药物研究所
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