Thin Films of Functionalized Multiwalled Carbon Nanotubes as Suitable Scaffold Materials for Stem Cells Proliferation and Bone Formation
文献类型：期刊论文
| 作者 | Nayak, Tapas R.1; Jian, Li1; Phua, Lee C.1; Ho, Han K.1; Ren, Yupeng2; Pastorin, Giorgia1 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2010-12 |
| 卷号 | 4期号:12页码:7717-7725 |
| 关键词 | mesenchymal stem cells carbon nanotubes functionalization cell differentiation bone osteogenesis |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/nn102738c |
| 文献子类 | Article |
| 英文摘要 | In the field of regenerative medicine, human mesenchymal stem cells envisage extremely promising applications, due to their ability to differentiate Into a wide range of connective tissue species on the basis of the substrate on which they grow. For the first time ever reported, we investigated the effects of a thin film of pegylated multiwalled carbon nanotubes spray dried onto preheated coverslips in terms of their ability to influence human mesenchymal stem cells' proliferation, morphology, and final differentiation into osteoblasts. Results dearly indicated that the homogeneous layer of functionalized nanotubes did not show any cytotoxicity and accelerated cell differentiation to a higher extent than carboxylated nanotubes or uncoated coverslips, by creating a more viable microenvironment for stem cells. Interestingly, cell differentiation occurred even in the absence of additional biochemical inducing agents, as evidenced by multiple independent criteria at the transcriptional, protein expression, and functional levels. Taken together, these findings suggest that functionalized carbon nanotubes represent a suitable scaffold toward a very selective differentiation into bone. |
| WOS关键词 | OSTEOGENIC DIFFERENTIATION ; FLUORESCENCE ASSAY ; NEURONAL GROWTH ; IN-VITRO ; BIOMATERIALS ; TOPOGRAPHY ; EXPRESSION ; VIABILITY ; TOXICITY |
| 资助项目 | National University of Singapore, Department of Pharmacy (FRC)[R-148-000-129-112] ; A-STAR[SERC R-148-001-435-305] ; MOE of Singapore[MOE2009-T2-2-011] ; MOE of Singapore[R-398-000-068-112] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000285449100085 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278696]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Pastorin, Giorgia |
| 作者单位 | 1.Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nayak, Tapas R.,Jian, Li,Phua, Lee C.,et al. Thin Films of Functionalized Multiwalled Carbon Nanotubes as Suitable Scaffold Materials for Stem Cells Proliferation and Bone Formation[J]. ACS NANO,2010,4(12):7717-7725. |
| APA | Nayak, Tapas R.,Jian, Li,Phua, Lee C.,Ho, Han K.,Ren, Yupeng,&Pastorin, Giorgia.(2010).Thin Films of Functionalized Multiwalled Carbon Nanotubes as Suitable Scaffold Materials for Stem Cells Proliferation and Bone Formation.ACS NANO,4(12),7717-7725. |
| MLA | Nayak, Tapas R.,et al."Thin Films of Functionalized Multiwalled Carbon Nanotubes as Suitable Scaffold Materials for Stem Cells Proliferation and Bone Formation".ACS NANO 4.12(2010):7717-7725. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。