Application of Plant Viruses as Nano Drug Delivery Systems
文献类型：期刊论文
| 作者 | Ren, Yupeng1; Wong, Sek Man3,4; Lim, Lee Yong2 |
| 刊名 | PHARMACEUTICAL RESEARCH
 |
| 出版日期 | 2010-11 |
| 卷号 | 27期号:11页码:2509-2513 |
| 关键词 | coat protein drug delivery plant virus protein cage |
| ISSN号 | 0724-8741 |
| DOI | 10.1007/s11095-010-0251-2 |
| 文献子类 | Editorial Material |
| 英文摘要 | Nano-sized drug delivery systems based on virus-derived platforms have promising delivery and targeting efficiencies. To date, much of our understanding of these systems is obtained from studies of animal viruses. Application of plant viruses for drug delivery is in the nascent stage, but it is becoming apparent that plant viral particles can be engineered to possess novel properties to meet the unique requirements of targeted drug delivery. Chemical functionalization of a plant viral particle surface can impart stealth properties to prolong in vivo circulation half-life and/or targeting capability to direct drug delivery to diseased tissues. The amino acid sequence of the viral coat protein can be genetically manipulated to yield protein cages of specific chemistry and morphology, while the conformation of the protein cage can be directed, via the external environment, to disassemble, then reassemble in vitro to exchange native viral genomic material with exogenous cargo. The purpose of this commentary is to evaluate current literature to assess the potential of nano-scale plant-virus-based drug delivery systems for the targeted delivery of chemotherapeutic agents. |
| WOS关键词 | COWPEA MOSAIC-VIRUS ; PROTEIN CAGES ; NANOPARTICLES ; PARTICLES |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000283368000025 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278743]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lim, Lee Yong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Univ Western Australia M315, Sch Biomed Biomol & Chem Sci, Pharm Program, Crawley, WA 6009, Australia; 3.Temasek Life Sci Lab, Singapore, Singapore; 4.Natl Univ Singapore, Dept Biol Sci, Singapore 117548, Singapore; |
| 推荐引用方式 GB/T 7714 | Ren, Yupeng,Wong, Sek Man,Lim, Lee Yong. Application of Plant Viruses as Nano Drug Delivery Systems[J]. PHARMACEUTICAL RESEARCH,2010,27(11):2509-2513. |
| APA | Ren, Yupeng,Wong, Sek Man,&Lim, Lee Yong.(2010).Application of Plant Viruses as Nano Drug Delivery Systems.PHARMACEUTICAL RESEARCH,27(11),2509-2513. |
| MLA | Ren, Yupeng,et al."Application of Plant Viruses as Nano Drug Delivery Systems".PHARMACEUTICAL RESEARCH 27.11(2010):2509-2513. |
入库方式： OAI收割
来源：上海药物研究所
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