A preclinical overview of metformin for the treatment of type 2 diabetes
文献类型：期刊论文
| 作者 | Zhou, Tingting1,3; Xu, Xin1; Du, Mengfan3; Zhao, Tong2; Wang, Jiaying2 |
| 刊名 | BIOMEDICINE & PHARMACOTHERAPY
 |
| 出版日期 | 2018-10 |
| 卷号 | 106页码:1227-1235 |
| 关键词 | Gluconeogenesis Insulin sensitivity Mechanism Metformin Type 2 diabetes (T2D) |
| ISSN号 | 0753-3322 |
| DOI | 10.1016/j.biopha.2018.07.085 |
| 文献子类 | Review |
| 英文摘要 | Type 2 diabetes (T2D) is the most common type of diabetes mellitus and is mainly characterized by insulin resistance, beta-cell dysfunction, and elevated hepatic glucose output. Metformin is a first-line antihyperglycemic agent that works mainly by regulating hepatic glucose production and peripheral insulin sensitivity. Metformin has been clinically applied for more than half a century, although the underlying pharmacological mechanisms remain elusive. This current review mainly focused on the development history of metformin and related preclinical studies on structural modification, pharmacological mechanisms for treatment of T2D, toxicology, pharmacokinetics, and pharmaceutics. The pharmacological function of metformin in lowering hyperglycemia suggests that multi-targeting could be an effective strategy for the discovery of new anti-diabetic drugs. A number of discoveries have revealed the pharmacologic mechanisms of metformin; however, precise mechanisms remain unclear. Deeper investigations on the biological features of metformin are expected to provide more rational applications and indications of this evergreen anti-T2D agent, which will in turn help to better understand the complicated pathogenesis of T2D. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; INHIBITS HEPATIC GLUCONEOGENESIS ; INTESTINAL GLUCOSE-ABSORPTION ; ORGANIC CATION TRANSPORTERS ; PANCREATIC BETA-CELLS ; IN-VIVO EVALUATION ; INSULIN-SECRETION ; SKELETAL-MUSCLE ; CLINICAL PHARMACOKINETICS ; SIGNALING PATHWAYS |
| 资助项目 | Fundamental Research Funds for the Central Universities[JUSRP11863] ; National Natural Science Foundation for Young Scientists of China[81703806] |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000442600300146 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279563]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhou, Tingting; Wang, Jiaying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 2.Nanjing Univ Chinese Med, Sch Med & Life Sci, State Key Lab Cultivat Base TCM Qual & Efficacy, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China 3.Jiangnan Univ, Wuxi Sch Med, 1800 Lihu Rd, Wuxi 214122, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Tingting,Xu, Xin,Du, Mengfan,et al. A preclinical overview of metformin for the treatment of type 2 diabetes[J]. BIOMEDICINE & PHARMACOTHERAPY,2018,106:1227-1235. |
| APA | Zhou, Tingting,Xu, Xin,Du, Mengfan,Zhao, Tong,&Wang, Jiaying.(2018).A preclinical overview of metformin for the treatment of type 2 diabetes.BIOMEDICINE & PHARMACOTHERAPY,106,1227-1235. |
| MLA | Zhou, Tingting,et al."A preclinical overview of metformin for the treatment of type 2 diabetes".BIOMEDICINE & PHARMACOTHERAPY 106(2018):1227-1235. |
入库方式： OAI收割
来源：上海药物研究所
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