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Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment

文献类型：期刊论文

作者Shi, Zhen1,4,5; Lan, Bin3; Peng, Baowei3; Wang, Xuefeng4; Zhang, Ganggang3; Li, Xiaohu2; Guo, Fang1,3,4,5
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2018-09-03
卷号503期号:1页码:249-256
关键词Melanoma BH3 mimetic Hyperthermia Combination therapy
ISSN号0006-291X
DOI10.1016/j.bbrc.2018.06.010
文献子类Article
英文摘要Malignant melanoma has shown increased incidence and high mortality rate in the last three decades. In this study, we investigated whether combination therapy with ch282-5 (a novel BH3 mimetic) and microwave hyperthermia could display synergistic antitumor effects against melanoma. Our results indicated that combination therapy reduced the viability and proliferation of melanoma cells. Through inhibiting the expression of anti-apoptotic proteins of Bcl-2 and IAP family and activating MAPK proteins, combined hyperthermia enhanced ch282-5-induced apoptosis. Combination therapy also synergistically disturbed the mTOR/p70S6k signaling pathway, which is important for cell survival and migration. Moreover, our results showed that combination therapy remarkably suppressed melanoma cell migration in vitro and significantly reduced experimental pulmonary metastasis in vivo. In conclusion, our results indicate that combination therapy with ch282-5 and hyperthermia has synergistic antitumor effects and provides a possible therapeutic strategy for advanced melanoma. (C) 2018 Elsevier Inc. All rights reserved.
WOS关键词MELANOMA ; CANCER ; METASTASIS ; RESISTANCE ; CISPLATIN ; MELPHALAN ; TOXICITY ; CELLS
资助项目National High Technology Research and Development Program of China[2013AA032201] ; National Natural Science Foundation of China[31171308] ; National Natural Science Foundation of China[81172208] ; National Natural Science Foundation of China[81472610] ; National Natural Science Foundation of China[81370842] ; National Basic Research Program[2011CB510106]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000441367800038
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/279591]  
专题中国科学院上海药物研究所
通讯作者Guo, Fang
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China;
2.Chinese Acad Sci, Shanghai Adv Res Inst, 99 Haike Rd, Shanghai 201210, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China;
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;
5.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China;
推荐引用方式
GB/T 7714		 Shi, Zhen,Lan, Bin,Peng, Baowei,et al. Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(1):249-256.
APA Shi, Zhen.,Lan, Bin.,Peng, Baowei.,Wang, Xuefeng.,Zhang, Ganggang.,...&Guo, Fang.(2018).Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,503(1),249-256.
MLA Shi, Zhen,et al."Combination therapy with BH3 mimetic and hyperthermia tends to be more effective on anti-melanoma treatment".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 503.1(2018):249-256.

入库方式： OAI收割

来源：上海药物研究所

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