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Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity

文献类型：期刊论文

作者Ma, Jiang1,2,3; Xia, Qingsu4; Fu, Peter P.4; Lin, Ge1,2,3
刊名JOURNAL OF FOOD AND DRUG ANALYSIS
出版日期2018-07
卷号26期号:3页码:965-972
关键词Pyrrolizidine alkaloids Pyrrole-protein adducts Covalent binding Target protein Mechanism-based biomarker Clinical diagnosis
ISSN号1021-9498
DOI10.1016/j.jfda.2018.05.005
文献子类Review
英文摘要Pyrrolizidine alkaloids (PAs) are phytotoxins identified in over 6000 plant species worldwide. Approximately 600 toxic PAs and PA N-oxides have been identified in about 3% flowering plants. PAs can cause toxicities in different organs particularly in the liver. The metabolic activation of PAs is catalyzed by hepatic cytochrome P450 and generates reactive pyrrolic metabolites that bind to cellular proteins to form pyrrole-protein adducts leading to PA-induced hepatotoxicity. The mechanisms that pyrrole-protein adducts induce toxicities have not been fully characterized. Methods for qualitative and quantitative detection of pyrrole-protein adducts have been developed and applied for the clinical diagnosis of PA exposure and PA-induced liver injury. This mini-review addresses the mechanisms of PA-induced hepatotoxicity mediated by pyrrole-protein adducts, the analytical methods for the detection of pyrrole-protein adducts, and the development of pyrrole-protein adducts as the mechanism-based biomarker of PA exposure and PA-induced hepatotoxicity. Copyright (C) 2018, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
WOS关键词SINUSOIDAL-OBSTRUCTION SYNDROME ; HEPATIC VENOOCCLUSIVE DISEASE ; ARTERY ENDOTHELIAL-CELLS ; DNA REACTIVE METABOLITE ; INDUCED LIVER-INJURY ; MONOCROTALINE PYRROLE ; PULMONARY-HYPERTENSION ; COVALENT BINDING ; MEDICINAL-PLANTS ; TUMOR INITIATION
资助项目Research Grants Council of Hong Kong[14110714] ; Research Grants Council of Hong Kong[14111816] ; Chinese University of Hong Kong (CUHK) for the Direct Grants[4054376] ; School of Biomedical Sciences-Seed Fund for Joint Establishments[00000000]
WOS研究方向Food Science & Technology ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000437809200003
出版者FOOD & DRUG ADMINSTRATION
源URL[http://119.78.100.183/handle/2S10ELR8/279682]  
专题中国科学院上海药物研究所
通讯作者Fu, Peter P.; Lin, Ge
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Beijing, Peoples R China;
2.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Hong Kong, Peoples R China;
3.Chinese Univ Hong Kong, Joint Res Lab Promoting Globalizat Tradit Chinese, Hong Kong, Hong Kong, Peoples R China;
4.US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA
推荐引用方式
GB/T 7714		 Ma, Jiang,Xia, Qingsu,Fu, Peter P.,et al. Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity[J]. JOURNAL OF FOOD AND DRUG ANALYSIS,2018,26(3):965-972.
APA Ma, Jiang,Xia, Qingsu,Fu, Peter P.,&Lin, Ge.(2018).Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity.JOURNAL OF FOOD AND DRUG ANALYSIS,26(3),965-972.
MLA Ma, Jiang,et al."Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity".JOURNAL OF FOOD AND DRUG ANALYSIS 26.3(2018):965-972.

入库方式： OAI收割

来源：上海药物研究所

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