The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential
文献类型：期刊论文
| 作者 | Peng, Dian1; Cao, Bin2; Zhou, Ying-Jun1; Long, Ya-Qiu3 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2018-04-10 |
| 卷号 | 149页码:148-169 |
| 关键词 | CXC chemokine receptor 4 Small molecule antagonists Structure-based optimization HIV-1 entry Tumor metastasis Inflammation Ischemia-reperfusion Autoimmune |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2018.02.043 |
| 文献子类 | Review |
| 英文摘要 | The CXC chemokine receptor 4 (CXCR4) is a highly reserved G-protein coupled 7-transmembrane (TM) chemokine receptor which consists of 352 amino acids. CXCR4 has only one endogenous chemokine ligand of CXCL12, besides several other natural nonchemokine ligands such as extracellular ubiquitin and noncognate ligand of MIF. CXCR4 strongly binds to CXCL12 and the resulting CXCLl2/CXCR4 axis is the molecular basis of their various biological functions, which include: (1) mediating immune and inflammatory response; (2) regulation of hematopoietic stem cell migration and homing; (3) an essential co-receptor for HIV entry into host cells; (4) participation in the process of embryonic development; (5) malignant tumor invasion and metastasis; (6) myocardial infarction, ischemic stroke and acute kidney injury. Correspondingly, CXCR4 antagonists find potential therapeutic applications in HIV infection, as well as hematopoietic stem cell migration, inflammation, immune-related diseases, tumor and ischemic diseases. Recently, great achievements have been made and a number of non-peptide CXCR4 antagonists with diversity scaffolds have been discovered. In this review, the discovery of small molecule CXCR4 antagonists focused on the structures, activities, evolution and development of representative CXCR4 antagonists is comprehensively described. The central role of CXCR4 in diverse cellular signaling pathways and its involvement in several diseases progressions are discussed as well. (C) 2018 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | CHEMOKINE RECEPTOR CXCR4 ; IMMUNODEFICIENCY-VIRUS TYPE-1 ; CELL-DERIVED FACTOR-1-ALPHA ; NON-HODGKINS-LYMPHOMA ; X4 HIV-1 REPLICATION ; LUNG-CANCER CELLS ; LEUKEMIA B-CELLS ; SMALL-MOLECULE ; MULTIPLE-MYELOMA ; FACTOR-I |
| 资助项目 | National Natural Science Foundation of China[81325020] ; National Natural Science Foundation of China[81361120410] ; National Natural Science Foundation of China[81761128022] ; National Natural Science Foundation of China[21772214] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000429186900015 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279808]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Long, Ya-Qiu |
| 作者单位 | 1.Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Soochow Univ, Coll Med, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Dian,Cao, Bin,Zhou, Ying-Jun,et al. The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018,149:148-169. |
| APA | Peng, Dian,Cao, Bin,Zhou, Ying-Jun,&Long, Ya-Qiu.(2018).The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,149,148-169. |
| MLA | Peng, Dian,et al."The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 149(2018):148-169. |
入库方式： OAI收割
来源：上海药物研究所
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