Intracisternal tuberculoma: a refractory type of tuberculoma indicating surgical intervention
文献类型：期刊论文
| 作者 | Chen, Fanfan3; Chen, Lei1; Cao, Yongfu3; Yi, Yongjun3; Zhuang, Jingwen3; Le, Wuhua3; Xie, Wei3; Tu, Lanbo3; Li, Peng3; Fang, Yimin4 |
| 刊名 | BMC NEUROLOGY
 |
| 出版日期 | 2018-01-18 |
| 卷号 | 18 |
| 关键词 | Central nervous system Paradoxical response Tuberculosis Spine Tuberculoma |
| ISSN号 | 1471-2377 |
| DOI | 10.1186/s12883-017-0996-x |
| 文献子类 | Article |
| 英文摘要 | Background: Central nervous system (CNS) tuberculoma is a rare disease with severe neurological deficits. This retrospective research is to review the data of patients diagnosed as CNS tuberculoma. Surgeries were performed in all patients. The clinical features especially the neurological image and the anatomical characters of the tuberculomas were concerned. Methods: Totally 11 patients diagnosed as CNS tuberculoma were admitted in Guangzhou First People's Hospital (7cases) and Changzheng Hospital (4 cases) during 2006-2015. The data including preoperative condition, neurological imaging, and surgical findings was collected and analyzed. Results: The lesions of nine patients (9/11) were totally or subtotally excised and two (2/11) were partially excised. Neurological functions of all patients were improved after surgery without secondary infection. Lesions of nine (9/11) patients preoperatively progressed as a result of paradoxical reaction. Of the 9 patients demonstrated paradoxical progression, all lesions were partially or totally located at the cisterns or the subarachnoid space. Preoperative ATTs lasted 2 to 12 months and tuberculomas were not eliminated. The arachnoid was found thickened and tightly adhered to the lesions during surgeries. Of the 2 cases that paradoxical reaction were excluded, both patients (case 6, intramedullary tuberculoma; case 11, intradural extramedullary tuberculoma) were admitted at onset of the disease. ATTs were preoperatively given for 1 week as neurological deficits aggravated. The tuberculous lesions of CNS or other system showed no obvious change and paradoxical reaction could not be established in both cases. Conclusions: Exudates of tuberculosis is usually accumulated in the cisterns and frequently results in the paradoxical formation of tuberculoma. Intracisternal tuberculoma is closely related to paradoxical reaction and refractory to anti-tuberculosis therapy. Micro-surgical excision is safe and effective. Early surgical intervention may be considered in the diagnosis of intracisternal tuberculoma especially when paradoxical reaction participates in the development of tuberculoma. |
| WOS关键词 | CENTRAL-NERVOUS-SYSTEM ; INTRADURAL EXTRAMEDULLARY TUBERCULOMA ; INTRACRANIAL TUBERCULOMAS ; SPINAL-CORD ; OPTICOCHIASMATIC ARACHNOIDITIS ; PARADOXICAL RESPONSE ; MENINGITIS ; SURGERY ; THERAPY ; BRAIN |
| 资助项目 | National Natural Science Fund of China[81302187] ; PLA logistics research project[CWS14C063] ; Fund of State Key Laboratory of Drug Research[SIMM1705KF-10] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000423119900001 |
| 出版者 | BIOMED CENTRAL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/272281]  |
| 专题 | 新药研究国家重点实验室 中科院受体结构与功能重点实验室 |
| 通讯作者 | He, Hua; Ju, Hongbin |
| 作者单位 | 1.Shenzhen Univ, Neurosurg Dept, Shenzhen Peoples Hosp 2, 3002 Sungang Rd, Shenzhen 518037, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 415 Fengyang Rd, Shanghai 200003, Peoples R China; 3.Guangzhou Med Univ, Neurosurg Dept, Guangzhou Peoples Hosp 1, 1 Panfu Rd, Guangzhou 510180, Guangdong, Peoples R China; 4.Guangzhou Chest Hosp, TB Dept, 62 Hengzhi Gang Rd, Guangzhou 510095, Guangdong, Peoples R China; 5.Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Record Dept, 1 Panfu Rd, Guangzhou 510180, Guangdong, Peoples R China; 6.Second Mil Med Univ, Dept Navy Med, 800 Xiangyin Rd, Shanghai 200433, Peoples R China; 7.Second Mil Med Univ, Changzheng Hosp, Neurosurg Dept, 415 Fengyang Rd, Shanghai 200003, Peoples R China; 8.Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Spinal Surg Dept, 1 Panfu Rd, Guangzhou 510180, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Fanfan,Chen, Lei,Cao, Yongfu,et al. Intracisternal tuberculoma: a refractory type of tuberculoma indicating surgical intervention[J]. BMC NEUROLOGY,2018,18. |
| APA | Chen, Fanfan.,Chen, Lei.,Cao, Yongfu.,Yi, Yongjun.,Zhuang, Jingwen.,...&Ju, Hongbin.(2018).Intracisternal tuberculoma: a refractory type of tuberculoma indicating surgical intervention.BMC NEUROLOGY,18. |
| MLA | Chen, Fanfan,et al."Intracisternal tuberculoma: a refractory type of tuberculoma indicating surgical intervention".BMC NEUROLOGY 18(2018). |
入库方式： OAI收割
来源：上海药物研究所
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